TY - JOUR
T1 - VLDL triglyceride kinetics in lean, overweight, and obese men and women
AU - Mittendorfer, Bettina
AU - Yoshino, Mihoko
AU - Patterson, Bruce W.
AU - Klein, Samuel
N1 - Funding Information:
This work was supported by National Institutes of Health grants DK 37948, AT 0110, AR 49869, HD 57796, DK 94483, DK 56341 (Washington University School of Medicine Nutrition and Obesity Research Center), DK 020579 (Washington University School of Medicine Diabetes Research Center), GM 103422 (Washington University School of Medicine Biomedical Mass Spectrometry Resource), UL1 TR000448 (Washington University School of Medicine Clinical Translational Science Award), T32 DK07296, and DK007120 (Diabetes Research Postdoctoral Training Program) and grants from the International Life Sciences Foundation, the American Heart Association (0365436Z and 0510015Z), and the Pershing Square Foundation. Disclosure Summary: The authors have nothing to disclose.
Publisher Copyright:
Copyright © 2016 by the Endocrine Society.
PY - 2016/11
Y1 - 2016/11
N2 - Context: High-plasma very low-density lipoprotein (VLDL) triglyceride (TG) concentration and alterations in VLDL-TG metabolism are associated with cardiometabolic disease. Objective: This study sought to evaluate the interrelationships among factors purported to regulate VLDL-TG metabolism in a large cohort ofmenandwomenwith a wide range in body adiposity and fat distribution but without diabetes. Subjects and Design: We assessed body composition and fat distribution, plasma insulin concentration, free fatty acid availability, and basal VLDL-TG and VLDL-apoB-100 (VLDL particle number) kinetics in 233 lean, overweight, and obese men and women. Results: We found that: 1) plasma VLDL-TG concentration is determined primarily by VLDL-TG secretion rate (SR) in men and by VLDL-TG clearance rate in women; 2) there is a dissociation between VLDL-TG and VLDL-apoB-100 SRs, and VLDL-apoB-100 SR only explains ∼30%of the variance in VLDL-TG SR; 3) ∼50%of people with obesity have high plasma VLDL-TG concentration due to both an increased VLDL-TG SR and a decreased rate of VLDL-TG plasma clearance, and they have lower plasma high-density lipoprotein-cholesterol concentration and more intra-abdominal and liver fat than those with normal VLDL-TG concentration; and 4) fat-free mass, liver fat content and the rate of free fatty acid release into plasma are independent predictors (with a sex × race interaction) of VLDL-TG SR. Conclusions: The regulation of plasma VLDL-TG concentration is complex and influenced by multiple metabolic factors.Manypeople with obesity have normal plasmaVLDL-TGconcentrationsand kinetics, whereas those with high plasma VLDL-TG concentrations have increased VLDL-TG SR and other markers of cardiometabolic disease risk. (J Clin Endocrinol Metab 101: 4151-4160, 2016).
AB - Context: High-plasma very low-density lipoprotein (VLDL) triglyceride (TG) concentration and alterations in VLDL-TG metabolism are associated with cardiometabolic disease. Objective: This study sought to evaluate the interrelationships among factors purported to regulate VLDL-TG metabolism in a large cohort ofmenandwomenwith a wide range in body adiposity and fat distribution but without diabetes. Subjects and Design: We assessed body composition and fat distribution, plasma insulin concentration, free fatty acid availability, and basal VLDL-TG and VLDL-apoB-100 (VLDL particle number) kinetics in 233 lean, overweight, and obese men and women. Results: We found that: 1) plasma VLDL-TG concentration is determined primarily by VLDL-TG secretion rate (SR) in men and by VLDL-TG clearance rate in women; 2) there is a dissociation between VLDL-TG and VLDL-apoB-100 SRs, and VLDL-apoB-100 SR only explains ∼30%of the variance in VLDL-TG SR; 3) ∼50%of people with obesity have high plasma VLDL-TG concentration due to both an increased VLDL-TG SR and a decreased rate of VLDL-TG plasma clearance, and they have lower plasma high-density lipoprotein-cholesterol concentration and more intra-abdominal and liver fat than those with normal VLDL-TG concentration; and 4) fat-free mass, liver fat content and the rate of free fatty acid release into plasma are independent predictors (with a sex × race interaction) of VLDL-TG SR. Conclusions: The regulation of plasma VLDL-TG concentration is complex and influenced by multiple metabolic factors.Manypeople with obesity have normal plasmaVLDL-TGconcentrationsand kinetics, whereas those with high plasma VLDL-TG concentrations have increased VLDL-TG SR and other markers of cardiometabolic disease risk. (J Clin Endocrinol Metab 101: 4151-4160, 2016).
UR - http://www.scopus.com/inward/record.url?scp=84994905153&partnerID=8YFLogxK
U2 - 10.1210/jc.2016-1500
DO - 10.1210/jc.2016-1500
M3 - Article
C2 - 27588438
AN - SCOPUS:84994905153
VL - 101
SP - 4151
EP - 4160
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 11
ER -