TY - JOUR
T1 - VLDL-triglyceride kinetics during hyperglycemia-hyperinsulinemia
T2 - Effects of sex and obesity
AU - Mittendorfer, Bettina
AU - Patterson, Bruce W.
AU - Klein, Samuel
AU - Sidossis, Labros S.
PY - 2003/4/1
Y1 - 2003/4/1
N2 - We have previously shown that sex and obesity independently affect basal very low density lipoprotein (VLDL)-triglyceride (TG) kinetics. In the present study, we investigated the effect of hyperglycemia-hyperinsulinemia on VLDL-TG kinetics in lean and obese men and women (n = 6 in each group). VLDL-TG kinetics were measured during basal, postabsorptive conditions and during glucose infusion (5.5 mg·kg FFM--1·min-1) by using [2H5]glycerol bolus injection in conjunction with compartmental modeling analysis. Basal VLDL-TG secretion in plasma was greater in obese than in lean men (7.8 ± 0.6 and 2.9 ± 0.4 μmol·l plasma-1·min-1; P < 0.001) but was not different in lean and obese women (5.0 ± 1.1 and 5.9 ± 1.1 μmol·l plasma-1·min-1). Glucose infusion decreased the VLDL-TG secretion rate by ∼50% in lean and obese men and in lean women (to 1.5 ± 0.4, 4.0 ± 0.6, and 2.2 ± 0.4 μmol·l plasma-1·min-1, respectively; all P < 0.05) but had no effect on the VLDL-TG secretion rate in obese women (4.9 ± 1.0 μmol·l plasma-1·min-1). These results demonstrate that both sex and adiposity affect the regulation of VLDL-TG metabolism. Glucose and insulin decrease VLDL-TG production in both lean men and lean women; obesity is associated with resistance to the glucose-and insulin-mediated suppression of VLDL-TG secretion in women, but not in men.
AB - We have previously shown that sex and obesity independently affect basal very low density lipoprotein (VLDL)-triglyceride (TG) kinetics. In the present study, we investigated the effect of hyperglycemia-hyperinsulinemia on VLDL-TG kinetics in lean and obese men and women (n = 6 in each group). VLDL-TG kinetics were measured during basal, postabsorptive conditions and during glucose infusion (5.5 mg·kg FFM--1·min-1) by using [2H5]glycerol bolus injection in conjunction with compartmental modeling analysis. Basal VLDL-TG secretion in plasma was greater in obese than in lean men (7.8 ± 0.6 and 2.9 ± 0.4 μmol·l plasma-1·min-1; P < 0.001) but was not different in lean and obese women (5.0 ± 1.1 and 5.9 ± 1.1 μmol·l plasma-1·min-1). Glucose infusion decreased the VLDL-TG secretion rate by ∼50% in lean and obese men and in lean women (to 1.5 ± 0.4, 4.0 ± 0.6, and 2.2 ± 0.4 μmol·l plasma-1·min-1, respectively; all P < 0.05) but had no effect on the VLDL-TG secretion rate in obese women (4.9 ± 1.0 μmol·l plasma-1·min-1). These results demonstrate that both sex and adiposity affect the regulation of VLDL-TG metabolism. Glucose and insulin decrease VLDL-TG production in both lean men and lean women; obesity is associated with resistance to the glucose-and insulin-mediated suppression of VLDL-TG secretion in women, but not in men.
KW - Coronary heart disease
KW - Hyperglycemia
KW - Hypertriglyceridemia
UR - http://www.scopus.com/inward/record.url?scp=0037376827&partnerID=8YFLogxK
U2 - 10.1152/ajpendo.00411.2002
DO - 10.1152/ajpendo.00411.2002
M3 - Article
C2 - 12475756
AN - SCOPUS:0037376827
SN - 0193-1849
VL - 284
SP - E708-E715
JO - American Journal of Physiology - Endocrinology and Metabolism
JF - American Journal of Physiology - Endocrinology and Metabolism
IS - 4 47-4
ER -