TY - JOUR
T1 - Vitamin K effects in human health
T2 - new insights beyond bone and cardiovascular health
AU - Fusaro, Maria
AU - Gallieni, Maurizio
AU - Porta, Camillo
AU - Nickolas, Thomas L.
AU - Khairallah, Pascale
N1 - Publisher Copyright:
© 2020, Italian Society of Nephrology.
PY - 2020/4/1
Y1 - 2020/4/1
N2 - Vitamin K is a cofactor for the function of the enzyme γ-glutamyl carboxylase, necessary for the activation of multiple vitamin K dependent-proteins. Vitamin K dependent-proteins (VKDPs) have important roles in bone health, vascular health, metabolism, reproduction as well as in cancer progression. Vitamin K deficiency is common in different conditions, including kidney disease, and it may influence the activity of VKDPs. This review discusses vitamin K status in human health and the physiologic and pathologic roles of VKDPs, beyond the established effects in skeletal and cardiovascular health.
AB - Vitamin K is a cofactor for the function of the enzyme γ-glutamyl carboxylase, necessary for the activation of multiple vitamin K dependent-proteins. Vitamin K dependent-proteins (VKDPs) have important roles in bone health, vascular health, metabolism, reproduction as well as in cancer progression. Vitamin K deficiency is common in different conditions, including kidney disease, and it may influence the activity of VKDPs. This review discusses vitamin K status in human health and the physiologic and pathologic roles of VKDPs, beyond the established effects in skeletal and cardiovascular health.
KW - Bone disease
KW - Cancer
KW - Chronic kidney disease
KW - Vascular calcifications
KW - Vitamin K
UR - https://www.scopus.com/pages/publications/85076916747
U2 - 10.1007/s40620-019-00685-0
DO - 10.1007/s40620-019-00685-0
M3 - Review article
C2 - 31858448
AN - SCOPUS:85076916747
SN - 1121-8428
VL - 33
SP - 239
EP - 249
JO - Journal of Nephrology
JF - Journal of Nephrology
IS - 2
ER -