@article{a3640e11519a4df8a44c8b6baffaef5e,
title = "Vitamin e intake from natural sources and head and neck cancer risk: A pooled analysis in the International Head and Neck Cancer Epidemiology consortium",
abstract = "Evidence for the possible effect of vitamin E on head and neck cancers (HNCs) is limited.Methods:We used individual-level pooled data from 10 case-control studies (5959 cases and 12 248 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium to assess the association between vitamin E intake from natural sources and cancer of the oral cavity/pharynx and larynx. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression models applied to quintile categories of nonalcohol energy-adjusted vitamin E intake.Results:Intake of vitamin E was inversely related to oral/pharyngeal cancer (OR for the fifth vs the first quintile category=0.59, 95% CI: 0.49-0.71; P for trend <0.001) and to laryngeal cancer (OR=0.67, 95% CI: 0.54-0.83, P for trend <0.001). There was, however, appreciable heterogeneity of the estimated effect across studies for oral/pharyngeal cancer. Inverse associations were generally observed for the anatomical subsites of oral and pharyngeal cancer and within covariate strata for both sites.Conclusion:Our findings suggest that greater vitamin E intake from foods may lower HNC risk, although we were not able to explain the heterogeneity observed across studies or rule out certain sources of bias.",
keywords = "Head and neck cancer, INHANCE, laryngeal cancer, oral and pharyngeal cancer, vitamin E",
author = "V. Edefonti and M. Hashibe and M. Parpinel and M. Ferraroni and F. Turati and D. Serraino and K. Matsuo and Olshan, {A. F.} and Zevallos, {J. P.} and Winn, {D. M.} and K. Moysich and Zhang, {Z. F.} and H. Morgenstern and F. Levi and K. Kelsey and M. McClean and C. Bosetti and S. Schantz and Yu, {G. P.} and P. Boffetta and Chuang, {S. C.} and {A Lee}, {Y. C.} and {La Vecchia}, C. and A. Decarli",
note = "Funding Information: The INHANCE Pooled Data Project was supported by grants from the National Institutes of Health (NIH), National Cancer Institute, (NCI) R03CA113157 and NIDCR R03DE016611. Individual studies were funded by the following grants: (1) Italy Multicenter study: Italian Association for Research on Cancer (AIRC), Italian League Against Cancer, and Italian Ministry of Research; (2) Swiss study: the Swiss Research against Cancer/Oncosuisse (KFS-700 and OCS-1633); (3) Los Angeles study: NIH (P50CA090388, R01DA011386, R03CA077954, T32CA009142, U01CA096134, R21ES011667) and the Alper Research Program for Environmental Genomics of the UCLA Jonsson Comprehensive Cancer Center; (4) Boston study: NIH (R01CA078609, R01CA100679); (5) US multicenter study: The Intramural Program of the NCI, NIH, USA; (6) MSKCC study: NIH (R01CA051845); (7) Japan study (2001– 2005): Scientific Research grant from the Ministry of Education, Science, Sports, Culture and Technology of Japan (17015052) and grant for the Third-Term Comprehensive 10-Year Strategy for Cancer Control from the Ministry of Health, Labor and Welfare of Japan (H20-002); (8) North Carolina (2002–2006) study; (9) Buffalo study; (10) Milan study (2006–2009): Italian Association for Cancer Research (AIRC Grant Number 10068), Italian Foundation for Cancer Research (FIRC), and Italian Ministry of Education (PRIN 2009 X8YCBN). FT was supported by a fellowship from FIRC. Publisher Copyright: {\textcopyright} 2015 Cancer Research UK. All rights reserved.",
year = "2015",
month = jun,
day = "30",
doi = "10.1038/bjc.2015.149",
language = "English",
volume = "113",
pages = "182--192",
journal = "British Journal of Cancer",
issn = "0007-0920",
number = "1",
}