Vitamin D promotes epithelial immunity by upregulating antimicrobial peptides, including LL-37, which have bactericidal activity against Staphylococcus aureus. We found that children with vitamin D deficiency or insufficiency [25-hydroxyvitamin D <30 ng/mL] were more likely to present with recurrent, rather than primary, S. aureus skin or soft tissue infection. Vitamin D sufficiency may be one of a myriad of host and environmental factors that can be directly impacted to reduce the frequency of S. aureus skin and soft tissue infection.

Original languageEnglish
Pages (from-to)544-545
Number of pages2
JournalPediatric Infectious Disease Journal
Issue number5
StatePublished - May 21 2015


  • 25-hydroxyVitamin D
  • LL-37
  • Staphylococcus aureus
  • Vitamin D
  • cathelicidin


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