Vitamin D sufficiency and staphylococcus aureus infection in children

Jeffrey W. Wang, Patrick G. Hogan, David A. Hunstad, Stephanie A. Fritz

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Vitamin D promotes epithelial immunity by upregulating antimicrobial peptides, including LL-37, which have bactericidal activity against Staphylococcus aureus. We found that children with vitamin D deficiency or insufficiency [25-hydroxyvitamin D <30 ng/mL] were more likely to present with recurrent, rather than primary, S. aureus skin or soft tissue infection. Vitamin D sufficiency may be one of a myriad of host and environmental factors that can be directly impacted to reduce the frequency of S. aureus skin and soft tissue infection.

Original languageEnglish
Pages (from-to)544-545
Number of pages2
JournalPediatric Infectious Disease Journal
Volume34
Issue number5
DOIs
StatePublished - May 21 2015

Keywords

  • 25-hydroxyVitamin D
  • LL-37
  • Staphylococcus aureus
  • Vitamin D
  • cathelicidin

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