TY - JOUR
T1 - Vitamin D deficiency is associated with worse cognitive performance and lower bone density in older african americans
AU - Wilkins, Consuelo H.
AU - Birge, Stanley J.
AU - Sheline, Yvette I.
AU - Morris, John C.
N1 - Funding Information:
Funding/Support: This study was supported by grants from the National Institutes of Health: K23 AG026768 (C.H.W.), P01 AG03991 (J.C.M.), P50 AG05681 (J.C.M.) and the Michigan Center for Urban African American Aging Research (C.H.W.).
PY - 2009/4
Y1 - 2009/4
N2 - Background: Vitamin D deficiency is common in older adults and is more prevalent among persons with darker pigmented skin. The detrimental effects of vitamin D deficiency on the bone are widely known; however, recent data suggest that vitamin D deficiency may contribute to other disorders, including low mood, cognitive impairment, and impaired mobility. Objective: The purpose of this study was to determine whether nonskeletal diseases such as depression, cognitive impairment, and physical disability, which have been associated with vitamin D deficiency, are more commonly seen in older African Americans. Design: In a cross-sectional study of60 older adults (30 African Americans and 30 European Americans), vitamin D status, cognitive performance, physical performance, and bone mineral density (BMD) were assessed. Differences between groups and differences between those with vitamin D deficiency and those with normal vitamin D levels were tested. Results: African Americans had a lower mean 25-hydroxyvi- tamin D level (17.98 ng/ml; SD, 6.9) compared to European Americans (25.20 ng/ml; SD, 7.0; p <.0001). Participants with vitamin D deficiency performed worse on a measure of cognitive performance, the Short Blessed Test (10.87 vs 6.31; p =.016); the Physical Performance Test (PPT) (27.00 vs 28.96; p =.039); and had lower BMD (0.823 vs 0.914; p=.005) and t scores (-1.29 vs -0.72; p =.008) of the hip. Among African Americans, vitamin D deficiency was associated with worse cognitive performance and lower BMD of the hip. Conclusions; Vitamin D deficiency in older African Americans was associated with worse cognitive performance and lower BMD of the hip.
AB - Background: Vitamin D deficiency is common in older adults and is more prevalent among persons with darker pigmented skin. The detrimental effects of vitamin D deficiency on the bone are widely known; however, recent data suggest that vitamin D deficiency may contribute to other disorders, including low mood, cognitive impairment, and impaired mobility. Objective: The purpose of this study was to determine whether nonskeletal diseases such as depression, cognitive impairment, and physical disability, which have been associated with vitamin D deficiency, are more commonly seen in older African Americans. Design: In a cross-sectional study of60 older adults (30 African Americans and 30 European Americans), vitamin D status, cognitive performance, physical performance, and bone mineral density (BMD) were assessed. Differences between groups and differences between those with vitamin D deficiency and those with normal vitamin D levels were tested. Results: African Americans had a lower mean 25-hydroxyvi- tamin D level (17.98 ng/ml; SD, 6.9) compared to European Americans (25.20 ng/ml; SD, 7.0; p <.0001). Participants with vitamin D deficiency performed worse on a measure of cognitive performance, the Short Blessed Test (10.87 vs 6.31; p =.016); the Physical Performance Test (PPT) (27.00 vs 28.96; p =.039); and had lower BMD (0.823 vs 0.914; p=.005) and t scores (-1.29 vs -0.72; p =.008) of the hip. Among African Americans, vitamin D deficiency was associated with worse cognitive performance and lower BMD of the hip. Conclusions; Vitamin D deficiency in older African Americans was associated with worse cognitive performance and lower BMD of the hip.
KW - African Americans
KW - Bone
KW - Cognitive functioning
KW - Vitamins and minerals
UR - http://www.scopus.com/inward/record.url?scp=66949126574&partnerID=8YFLogxK
U2 - 10.1016/S0027-9684(15)30883-X
DO - 10.1016/S0027-9684(15)30883-X
M3 - Article
C2 - 19397226
AN - SCOPUS:66949126574
SN - 0027-9684
VL - 101
SP - 349
EP - 354
JO - Journal of the National Medical Association
JF - Journal of the National Medical Association
IS - 4
ER -