TY - JOUR
T1 - Vitamin D deficiency and comorbidities in children with sickle cell anemia
AU - Jackson, Tara Christine
AU - Krauss, Melissa Jo
AU - Debaun, Michael Rutledge
AU - Strunk, Robert Charles
AU - Arbeláez, Ana Maria
N1 - Funding Information:
This publication was made possible in part by grant UL1RR24992 from the National Institutes of Health (NIH). Its contents are solely the responsibility of the authors and do not necessarily represent the official view of NIH. The Sleep and Asthma Cohort Study (SAC) was conducted and supported by the National Heart, Lung, and Blood Institute in collaboration with site investigators. This paper was not prepared in collaboration with investigators of the SAC trial and does not necessarily reflect the opinions or views of the Cooperative Study of Sickle Cell Disease or the National Heart, Lung, and Blood Institute.
PY - 2012/4
Y1 - 2012/4
N2 - Vitamin D deficiency is known to be common among patients with sickle cell anemia (SCA). Vitamin D levels were measured in 139 children (aged 7.9 to 15.1 years) to study its association with SCA morbidities; severe deficiency <10 ng/mL was present in 64.0% and only 2.2% were sufficient (>30 ng/mL). Vitamin D levels were associated with pulmonary function (forced expiratory volume in 1 second [FEV1]), but not associated with either rates of acute pain or acute chest syndrome episodes. Further studies are needed to be able to compare outcomes in those with deficiency to those with sufficiency, as well as to treating patients with SCA with vitamin D to better establish a possible link, if any, between vitamin D and SCA morbidity.
AB - Vitamin D deficiency is known to be common among patients with sickle cell anemia (SCA). Vitamin D levels were measured in 139 children (aged 7.9 to 15.1 years) to study its association with SCA morbidities; severe deficiency <10 ng/mL was present in 64.0% and only 2.2% were sufficient (>30 ng/mL). Vitamin D levels were associated with pulmonary function (forced expiratory volume in 1 second [FEV1]), but not associated with either rates of acute pain or acute chest syndrome episodes. Further studies are needed to be able to compare outcomes in those with deficiency to those with sufficiency, as well as to treating patients with SCA with vitamin D to better establish a possible link, if any, between vitamin D and SCA morbidity.
KW - Acute chest syndrome
KW - Asthma
KW - Pain crisis
KW - Sickle cell anemia
KW - Vitamin D
UR - http://www.scopus.com/inward/record.url?scp=84859458161&partnerID=8YFLogxK
U2 - 10.3109/08880018.2012.661034
DO - 10.3109/08880018.2012.661034
M3 - Article
C2 - 22475302
AN - SCOPUS:84859458161
SN - 0888-0018
VL - 29
SP - 261
EP - 266
JO - Pediatric Hematology and Oncology
JF - Pediatric Hematology and Oncology
IS - 3
ER -