Vitamin D deficiency and comorbidities in children with sickle cell anemia

Tara Christine Jackson, Melissa Jo Krauss, Michael Rutledge Debaun, Robert Charles Strunk, Ana Maria Arbeláez

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Vitamin D deficiency is known to be common among patients with sickle cell anemia (SCA). Vitamin D levels were measured in 139 children (aged 7.9 to 15.1 years) to study its association with SCA morbidities; severe deficiency <10 ng/mL was present in 64.0% and only 2.2% were sufficient (>30 ng/mL). Vitamin D levels were associated with pulmonary function (forced expiratory volume in 1 second [FEV1]), but not associated with either rates of acute pain or acute chest syndrome episodes. Further studies are needed to be able to compare outcomes in those with deficiency to those with sufficiency, as well as to treating patients with SCA with vitamin D to better establish a possible link, if any, between vitamin D and SCA morbidity.

Original languageEnglish
Pages (from-to)261-266
Number of pages6
JournalPediatric Hematology and Oncology
Issue number3
StatePublished - Apr 2012


  • Acute chest syndrome
  • Asthma
  • Pain crisis
  • Sickle cell anemia
  • Vitamin D


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