Vital involvement of a natural killer cell activation receptor in resistance to viral infection

M. G. Brown, A. O. Dokun, J. W. Heusel, H. R.C. Smith, D. L. Beckman, E. A. Blattenberger, C. E. Dubbelde, L. R. Stone, A. A. Scalzo, W. M. Yokoyama

Research output: Contribution to journalArticlepeer-review

493 Scopus citations

Abstract

Natural killer (NK) cells are lymphocytes that can be distinguished from T and B cells through their involvement in innate immunity and their lack of rearranged antigen receptors. Although NK cells and their receptors were initially characterized in terms of tumor killing in vitro, we have determined that the NK cell activation receptor, Ly-49H, is critically involved in resistance to murine cytomegalovirus in vivo. Ly-49H requires an immunoreceptor tyrosine-based activation motif (ITAM)-containing transmembrane rnolecule for expression and signal transduction. Thus, NK cells use receptors functionally resembling ITAM-coupled T and B cell antigen receptors to provide vital innate host defense.

Original languageEnglish
Pages (from-to)934-937
Number of pages4
JournalScience
Volume292
Issue number5518
DOIs
StatePublished - May 4 2001

Fingerprint

Dive into the research topics of 'Vital involvement of a natural killer cell activation receptor in resistance to viral infection'. Together they form a unique fingerprint.

Cite this