Visual P300 and the self-directedness scale of the temperament and character inventory

Andrei B. Vedeniapin, Andrey P. Anokhin, Erik Sirevaag, John W. Rohrbaugh, C. Robert Cloninger

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Reduced amplitude of the P300 event-related brain potential has been associated with several psychopathological conditions and is thought to represent brain dysfunction in such conditions. Predisposition to personality disorders and psychopathology in general is also associated with low scores on the self-directedness (SD) scale of the Temperament and Character Inventory. The present preliminary study investigated the relationship between amplitudes of P300 elicited by rare target stimuli in a visual oddball task and SD scores in 58 healthy participants. P300 was found to be significantly reduced in subjects with low SD, as supported by correlational analysis and by comparison of groups formed on the basis of SD scores. This finding may be relevant to prior findings indicating reduced P300 amplitudes in a variety of psychopathological conditions and suggests that a common vulnerability factor, reflected in the low SD personality scores, may contribute to the P300 reduction in psychiatric populations.

Original languageEnglish
Pages (from-to)145-156
Number of pages12
JournalPsychiatry Research
Issue number2
StatePublished - Mar 25 2001


  • Character
  • Event-related potentials
  • Personality
  • Psychopathology


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