Visual Morbidity in Ocular Tuberculosis–Collaborative Ocular Tuberculosis Study (COTS)-1: Report #6

Rupesh Agrawal; Dinesh Visva Gunasekeran; Aniruddha Agarwal; Ilaria Testi; Ester Carreño; Mark Westcott; Sarakshi Mahajan; Dhananjay Raje; Kanika Aggarwal; Somasheila I. Murthy; Soon Phaik Chee; Peter Mccluskey; Su Ling Ho; Stephen Teoh; Luca Cimino; Jyotirmay Biswas; Shishir Narain; Manisha Agarwal; Padmamalini Mahendradas; Moncef Khairallah; Nicholas Jones; Ilknur Tugal-Tutkun; Kalpana Babu; Soumayava Basu; Richard Lee; Hassan Al-Dhibi; Bahram Bodaghi; Alessandro Invernizzi; Debra A. Goldstein; Carl P. Herbort; Talin Barisani-Asenbauer; Julio J. González-López; Sofia Androudi; Reema Bansal; Bruttendu Moharana; Simona Degli Esposti; Anastasia Tasiopoulou; Sengal Nadarajah; Mamta Agarwal; Sharanaya Abraham; Ruchi Vala; Ramandeep Singh; Aman Sharma; Kusum Sharma; Manfred Zierhut; Onn Min Kon; Emmett T. Cunningham; John H. Kempen; Quan Dong Nguyen; Carlos Pavesio; Vishali Gupta

doi:10.1080/09273948.2020.1774905

Visual Morbidity in Ocular Tuberculosis–Collaborative Ocular Tuberculosis Study (COTS)-1: Report #6

Rupesh Agrawal, Dinesh Visva Gunasekeran, Aniruddha Agarwal, Ilaria Testi, Ester Carreño, Mark Westcott, Sarakshi Mahajan, Dhananjay Raje, Kanika Aggarwal, Somasheila I. Murthy, Soon Phaik Chee, Peter Mccluskey, Su Ling Ho, Stephen Teoh, Luca Cimino, Jyotirmay Biswas, Shishir Narain, Manisha Agarwal, Padmamalini Mahendradas, Moncef KhairallahNicholas Jones, Ilknur Tugal-Tutkun, Kalpana Babu, Soumayava Basu, Richard Lee, Hassan Al-Dhibi, Bahram Bodaghi, Alessandro Invernizzi, Debra A. Goldstein, Carl P. Herbort, Talin Barisani-Asenbauer, Julio J. González-López, Sofia Androudi, Reema Bansal, Bruttendu Moharana, Simona Degli Esposti, Anastasia Tasiopoulou, Sengal Nadarajah, Mamta Agarwal, Sharanaya Abraham, Ruchi Vala, Ramandeep Singh, Aman Sharma, Kusum Sharma, Manfred Zierhut, Onn Min Kon, Emmett T. Cunningham, John H. Kempen, Quan Dong Nguyen, Carlos Pavesio, Vishali Gupta

Division of Hospital Medicine

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Objective: Aim of the study was to examine extent, natural history, and clinical features associated with visual impairment (VI) in patients diagnosed with ocular tuberculosis (OTB) by the Collaborative Ocular Tuberculosis Study (COTS)-1. Methods: Multi-center retrospective cohort study. Main outcomes were VI. Results: A total of 302 patients were included in the study, including 175 patients whose data related to BCVA were available throughout the 2 years of follow up. Mean BCVA grossly improved at 12, 18, and 24 months of follow-up (p < .001). Mean BCVA was worse at 12–18th month follow-up for patients treated with ATT versus patients who were not treated with ATT, but patients treated with ATT had a statistically significant improvement in BCVA at the 24-month endpoint. Conclusions: OTB is associated with significant visual morbidity, future well-designed prospective studies are warranted to establish the causal association between OTB and visual loss.

Original language	English
Pages (from-to)	49-57
Number of pages	9
Journal	Ocular Immunology and Inflammation
Volume	28
Issue number	sup1
DOIs	https://doi.org/10.1080/09273948.2020.1774905
State	Published - 2020

Keywords

Tuberculosis
blindness
uveitis
visual impairment
visual morbidity

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Agrawal, R., Gunasekeran, D. V., Agarwal, A., Testi, I., Carreño, E., Westcott, M., Mahajan, S., Raje, D., Aggarwal, K., Murthy, S. I., Chee, S. P., Mccluskey, P., Ho, S. L., Teoh, S., Cimino, L., Biswas, J., Narain, S., Agarwal, M., Mahendradas, P., ... Gupta, V. (2020). Visual Morbidity in Ocular Tuberculosis–Collaborative Ocular Tuberculosis Study (COTS)-1: Report #6. Ocular Immunology and Inflammation, 28(sup1), 49-57. https://doi.org/10.1080/09273948.2020.1774905

@article{3b49eb83e6c9445095bc03d4809b10ea,

title = "Visual Morbidity in Ocular Tuberculosis–Collaborative Ocular Tuberculosis Study (COTS)-1: Report #6",

abstract = "Objective: Aim of the study was to examine extent, natural history, and clinical features associated with visual impairment (VI) in patients diagnosed with ocular tuberculosis (OTB) by the Collaborative Ocular Tuberculosis Study (COTS)-1. Methods: Multi-center retrospective cohort study. Main outcomes were VI. Results: A total of 302 patients were included in the study, including 175 patients whose data related to BCVA were available throughout the 2 years of follow up. Mean BCVA grossly improved at 12, 18, and 24 months of follow-up (p < .001). Mean BCVA was worse at 12–18th month follow-up for patients treated with ATT versus patients who were not treated with ATT, but patients treated with ATT had a statistically significant improvement in BCVA at the 24-month endpoint. Conclusions: OTB is associated with significant visual morbidity, future well-designed prospective studies are warranted to establish the causal association between OTB and visual loss.",

keywords = "Tuberculosis, blindness, uveitis, visual impairment, visual morbidity",

author = "Rupesh Agrawal and Gunasekeran, {Dinesh Visva} and Aniruddha Agarwal and Ilaria Testi and Ester Carre{\~n}o and Mark Westcott and Sarakshi Mahajan and Dhananjay Raje and Kanika Aggarwal and Murthy, {Somasheila I.} and Chee, {Soon Phaik} and Peter Mccluskey and Ho, {Su Ling} and Stephen Teoh and Luca Cimino and Jyotirmay Biswas and Shishir Narain and Manisha Agarwal and Padmamalini Mahendradas and Moncef Khairallah and Nicholas Jones and Ilknur Tugal-Tutkun and Kalpana Babu and Soumayava Basu and Richard Lee and Hassan Al-Dhibi and Bahram Bodaghi and Alessandro Invernizzi and Goldstein, {Debra A.} and Herbort, {Carl P.} and Talin Barisani-Asenbauer and Gonz{\'a}lez-L{\'o}pez, {Julio J.} and Sofia Androudi and Reema Bansal and Bruttendu Moharana and Esposti, {Simona Degli} and Anastasia Tasiopoulou and Sengal Nadarajah and Mamta Agarwal and Sharanaya Abraham and Ruchi Vala and Ramandeep Singh and Aman Sharma and Kusum Sharma and Manfred Zierhut and Kon, {Onn Min} and Cunningham, {Emmett T.} and Kempen, {John H.} and Nguyen, {Quan Dong} and Carlos Pavesio and Vishali Gupta",

note = "Publisher Copyright: {\textcopyright} 2020 Taylor & Francis Group, LLC.",

year = "2020",

doi = "10.1080/09273948.2020.1774905",

language = "English",

volume = "28",

pages = "49--57",

journal = "Ocular Immunology and Inflammation",

issn = "0927-3948",

number = "sup1",

}

Agrawal, R, Gunasekeran, DV, Agarwal, A, Testi, I, Carreño, E, Westcott, M, Mahajan, S, Raje, D, Aggarwal, K, Murthy, SI, Chee, SP, Mccluskey, P, Ho, SL, Teoh, S, Cimino, L, Biswas, J, Narain, S, Agarwal, M, Mahendradas, P, Khairallah, M, Jones, N, Tugal-Tutkun, I, Babu, K, Basu, S, Lee, R, Al-Dhibi, H, Bodaghi, B, Invernizzi, A, Goldstein, DA, Herbort, CP, Barisani-Asenbauer, T, González-López, JJ, Androudi, S, Bansal, R, Moharana, B, Esposti, SD, Tasiopoulou, A, Nadarajah, S, Agarwal, M, Abraham, S, Vala, R, Singh, R, Sharma, A, Sharma, K, Zierhut, M, Kon, OM, Cunningham, ET, Kempen, JH, Nguyen, QD, Pavesio, C & Gupta, V 2020, 'Visual Morbidity in Ocular Tuberculosis–Collaborative Ocular Tuberculosis Study (COTS)-1: Report #6', Ocular Immunology and Inflammation, vol. 28, no. sup1, pp. 49-57. https://doi.org/10.1080/09273948.2020.1774905

TY - JOUR

T1 - Visual Morbidity in Ocular Tuberculosis–Collaborative Ocular Tuberculosis Study (COTS)-1

T2 - Report #6

AU - Agrawal, Rupesh

AU - Gunasekeran, Dinesh Visva

AU - Agarwal, Aniruddha

AU - Testi, Ilaria

AU - Carreño, Ester

AU - Westcott, Mark

AU - Mahajan, Sarakshi

AU - Raje, Dhananjay

AU - Aggarwal, Kanika

AU - Murthy, Somasheila I.

AU - Chee, Soon Phaik

AU - Mccluskey, Peter

AU - Ho, Su Ling

AU - Teoh, Stephen

AU - Cimino, Luca

AU - Biswas, Jyotirmay

AU - Narain, Shishir

AU - Agarwal, Manisha

AU - Mahendradas, Padmamalini

AU - Khairallah, Moncef

AU - Jones, Nicholas

AU - Tugal-Tutkun, Ilknur

AU - Babu, Kalpana

AU - Basu, Soumayava

AU - Lee, Richard

AU - Al-Dhibi, Hassan

AU - Bodaghi, Bahram

AU - Invernizzi, Alessandro

AU - Goldstein, Debra A.

AU - Herbort, Carl P.

AU - Barisani-Asenbauer, Talin

AU - González-López, Julio J.

AU - Androudi, Sofia

AU - Bansal, Reema

AU - Moharana, Bruttendu

AU - Esposti, Simona Degli

AU - Tasiopoulou, Anastasia

AU - Nadarajah, Sengal

AU - Agarwal, Mamta

AU - Abraham, Sharanaya

AU - Vala, Ruchi

AU - Singh, Ramandeep

AU - Sharma, Aman

AU - Sharma, Kusum

AU - Zierhut, Manfred

AU - Kon, Onn Min

AU - Cunningham, Emmett T.

AU - Kempen, John H.

AU - Nguyen, Quan Dong

AU - Pavesio, Carlos

AU - Gupta, Vishali

PY - 2020

Y1 - 2020

N2 - Objective: Aim of the study was to examine extent, natural history, and clinical features associated with visual impairment (VI) in patients diagnosed with ocular tuberculosis (OTB) by the Collaborative Ocular Tuberculosis Study (COTS)-1. Methods: Multi-center retrospective cohort study. Main outcomes were VI. Results: A total of 302 patients were included in the study, including 175 patients whose data related to BCVA were available throughout the 2 years of follow up. Mean BCVA grossly improved at 12, 18, and 24 months of follow-up (p < .001). Mean BCVA was worse at 12–18th month follow-up for patients treated with ATT versus patients who were not treated with ATT, but patients treated with ATT had a statistically significant improvement in BCVA at the 24-month endpoint. Conclusions: OTB is associated with significant visual morbidity, future well-designed prospective studies are warranted to establish the causal association between OTB and visual loss.

AB - Objective: Aim of the study was to examine extent, natural history, and clinical features associated with visual impairment (VI) in patients diagnosed with ocular tuberculosis (OTB) by the Collaborative Ocular Tuberculosis Study (COTS)-1. Methods: Multi-center retrospective cohort study. Main outcomes were VI. Results: A total of 302 patients were included in the study, including 175 patients whose data related to BCVA were available throughout the 2 years of follow up. Mean BCVA grossly improved at 12, 18, and 24 months of follow-up (p < .001). Mean BCVA was worse at 12–18th month follow-up for patients treated with ATT versus patients who were not treated with ATT, but patients treated with ATT had a statistically significant improvement in BCVA at the 24-month endpoint. Conclusions: OTB is associated with significant visual morbidity, future well-designed prospective studies are warranted to establish the causal association between OTB and visual loss.

KW - Tuberculosis

KW - blindness

KW - uveitis

KW - visual impairment

KW - visual morbidity

UR - http://www.scopus.com/inward/record.url?scp=85087494966&partnerID=8YFLogxK

U2 - 10.1080/09273948.2020.1774905

DO - 10.1080/09273948.2020.1774905

M3 - Article

C2 - 32600169

AN - SCOPUS:85087494966

SN - 0927-3948

VL - 28

SP - 49

EP - 57

JO - Ocular Immunology and Inflammation

JF - Ocular Immunology and Inflammation

IS - sup1

ER -

Visual Morbidity in Ocular Tuberculosis–Collaborative Ocular Tuberculosis Study (COTS)-1: Report #6

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Keywords

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