TY - JOUR
T1 - Visual field progression patterns in the ocular hypertension treatment study correspond to vulnerability regions of the disc
AU - Leshno, Ari
AU - Bommakanti, Nikhil
AU - De Moraes, Carlos Gustavo
AU - Gordon, Mae O.
AU - Kass, Michael A.
AU - Cioffi, George A.
AU - Liebmann, Jeffrey M.
N1 - Publisher Copyright:
© The Author(s), under exclusive licence to The Royal College of Ophthalmologists 2024.
PY - 2024/6
Y1 - 2024/6
N2 - Objectives: To determine the locations on the 24-2 visual field (VF) testing grid that are most likely to progress in patients with ocular hypertension (OHTN). Based on a structural model of superior and inferior areas of relative vulnerability at the optic disc, we hypothesized that the nasal and paracentral regions are more prone to show a reduction in sensitivity. Methods: Posthoc analysis of data collected in phases 1 and 2 of the Ocular Hypertension Treatment Study (OHTS). A pointwise analysis was applied to determine the progression patterns in the early and delayed treatment groups. Each group’s progression rate and frequency were calculated for each of the 52 locations corresponding to the 24-2 VF strategy, using trend- and event-based analyses, respectively. Results: For the event-based analysis, the events were most commonly found in the nasal and paracentral regions. The same regions, with some modest variation, were found to have the fastest rates of progression (ROP) measured with trend analysis. A similar pattern of progression was observed in both the early and delayed treatment groups. The difference in event rates and ROP between the early and delayed treatment groups was also greatest in the nasal and paracentral regions. Conclusions: Development of VF loss in ocular hypertensive eyes appears to be consistent with the vulnerability zones previously described in glaucomatous eyes with established VF loss. Ocular hypotensive treatment likely helps to slow the rate of progression in these regions. This suggests that careful monitoring of these locations may be useful.
AB - Objectives: To determine the locations on the 24-2 visual field (VF) testing grid that are most likely to progress in patients with ocular hypertension (OHTN). Based on a structural model of superior and inferior areas of relative vulnerability at the optic disc, we hypothesized that the nasal and paracentral regions are more prone to show a reduction in sensitivity. Methods: Posthoc analysis of data collected in phases 1 and 2 of the Ocular Hypertension Treatment Study (OHTS). A pointwise analysis was applied to determine the progression patterns in the early and delayed treatment groups. Each group’s progression rate and frequency were calculated for each of the 52 locations corresponding to the 24-2 VF strategy, using trend- and event-based analyses, respectively. Results: For the event-based analysis, the events were most commonly found in the nasal and paracentral regions. The same regions, with some modest variation, were found to have the fastest rates of progression (ROP) measured with trend analysis. A similar pattern of progression was observed in both the early and delayed treatment groups. The difference in event rates and ROP between the early and delayed treatment groups was also greatest in the nasal and paracentral regions. Conclusions: Development of VF loss in ocular hypertensive eyes appears to be consistent with the vulnerability zones previously described in glaucomatous eyes with established VF loss. Ocular hypotensive treatment likely helps to slow the rate of progression in these regions. This suggests that careful monitoring of these locations may be useful.
UR - http://www.scopus.com/inward/record.url?scp=85185100527&partnerID=8YFLogxK
U2 - 10.1038/s41433-024-02949-x
DO - 10.1038/s41433-024-02949-x
M3 - Article
C2 - 38355667
AN - SCOPUS:85185100527
SN - 0950-222X
VL - 38
SP - 1549
EP - 1555
JO - Eye (Basingstoke)
JF - Eye (Basingstoke)
IS - 8
ER -