TY - JOUR
T1 - Virus-related collapsing glomerulopathy, a common mechanism of injury?
AU - Gaut, Joseph P.
N1 - Publisher Copyright:
© 2022 International Society of Nephrology
PY - 2022/5
Y1 - 2022/5
N2 - Collapsing glomerulopathy frequently shows focal lesions on biopsy, creating challenges with transcriptomic investigations because of inadequate tissue sample. This challenge is overcome with spatial transcriptomics, technology linking transcriptomic data to histology. Applying this technology to investigate patients with collapsing glomerulopathy related to HIV infection or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Smith et al. provide provocative evidence that collapsing glomerulopathy may have different molecular signatures despite the similar morphologic appearance.
AB - Collapsing glomerulopathy frequently shows focal lesions on biopsy, creating challenges with transcriptomic investigations because of inadequate tissue sample. This challenge is overcome with spatial transcriptomics, technology linking transcriptomic data to histology. Applying this technology to investigate patients with collapsing glomerulopathy related to HIV infection or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Smith et al. provide provocative evidence that collapsing glomerulopathy may have different molecular signatures despite the similar morphologic appearance.
UR - http://www.scopus.com/inward/record.url?scp=85128231247&partnerID=8YFLogxK
U2 - 10.1016/j.kint.2022.02.009
DO - 10.1016/j.kint.2022.02.009
M3 - Comment/debate
C2 - 35461615
AN - SCOPUS:85128231247
SN - 0085-2538
VL - 101
SP - 880
EP - 882
JO - Kidney International
JF - Kidney International
IS - 5
ER -