Virome genomics: A tool for defining the human virome

Kristine M. Wylie, George M. Weinstock, Gregory A. Storch

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations

Abstract

High throughput, deep sequencing assays are powerful tools for gaining insights into virus-host interactions. Sequencing assays can discover novel viruses and describe the genomes of novel and known viruses. Genomic information can predict viral proteins that can be characterized, describe important genes in the host that control infections, and evaluate gene expression of viruses and hosts during infection. Sequencing can also describe variation and evolution of viruses during replication and transmission. This review recounts some of the major advances in the studies of virus-host interactions from the last two years, and discusses the uses of sequencing technologies relating to these studies.

Original languageEnglish
Pages (from-to)479-484
Number of pages6
JournalCurrent Opinion in Microbiology
Volume16
Issue number4
DOIs
StatePublished - Aug 2013

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