TY - JOUR
T1 - Viral surveillance and subclinical viral infection in pediatric kidney transplantation
AU - Smith, Jodi M.
AU - Dharnidharka, Vikas R.
N1 - Publisher Copyright:
© 2014, IPNA.
PY - 2015/5/1
Y1 - 2015/5/1
N2 - The more potent immunosuppressive therapy that has successfully reduced the incidence of acute rejection and improved graft outcomes has also resulted in a higher incidence of viral complications. Sensitive molecular methods now allow for the detection of subclinical viral infection, which is increasingly recognized due to the adoption of routine post-transplant viral surveillance protocols. The goal of viral surveillance is the detection of subclinical viral infection that triggers an intervention; one that either prevents progression to viral disease or leads to early diagnosis of viral disease, which is associated with improved outcomes. Knowledge of the epidemiology and natural history of subclinical viral infection and viral disease, as well as patient-specific risk factors, is required to establish the optimal surveillance schedule which achieves the goal of early diagnosis. Evidence that detection of subclinical viral infection can impact viral disease is variable depending on the virus. This review will summarize the current data on the role of viral surveillance for BK virus (BKV), cytomegalovirus (CMV), and the Epstein–Barr virus (EBV) in the pediatric kidney transplant population.
AB - The more potent immunosuppressive therapy that has successfully reduced the incidence of acute rejection and improved graft outcomes has also resulted in a higher incidence of viral complications. Sensitive molecular methods now allow for the detection of subclinical viral infection, which is increasingly recognized due to the adoption of routine post-transplant viral surveillance protocols. The goal of viral surveillance is the detection of subclinical viral infection that triggers an intervention; one that either prevents progression to viral disease or leads to early diagnosis of viral disease, which is associated with improved outcomes. Knowledge of the epidemiology and natural history of subclinical viral infection and viral disease, as well as patient-specific risk factors, is required to establish the optimal surveillance schedule which achieves the goal of early diagnosis. Evidence that detection of subclinical viral infection can impact viral disease is variable depending on the virus. This review will summarize the current data on the role of viral surveillance for BK virus (BKV), cytomegalovirus (CMV), and the Epstein–Barr virus (EBV) in the pediatric kidney transplant population.
KW - Kidney transplant
KW - Pediatric
KW - Subclinical infection
KW - Viral surveillance
UR - http://www.scopus.com/inward/record.url?scp=84939880209&partnerID=8YFLogxK
U2 - 10.1007/s00467-014-2866-8
DO - 10.1007/s00467-014-2866-8
M3 - Article
C2 - 25125226
AN - SCOPUS:84939880209
SN - 0931-041X
VL - 30
SP - 741
EP - 748
JO - Pediatric Nephrology
JF - Pediatric Nephrology
IS - 5
ER -