Viral protein R of human immunodeficiency virus types 1 and 2 is dispensable for replication and cytopathogenicity in lymphoid cells

D. Dedera; W. Hu; N. Vander Heyden; L. Ratner

doi:10.1128/jvi.63.7.3205-3208.1989

Viral protein R of human immunodeficiency virus types 1 and 2 is dispensable for replication and cytopathogenicity in lymphoid cells

D. Dedera, W. Hu, N. Vander Heyden, L. Ratner

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Abstract

Viral protein R (VPR) is conserved in human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2). To assess its function, we have constructed mutations within the vpr coding regions of HIV-1 and HIV-2 predicted to express truncated VPR products. Infectious virus was produced by each proviral clone and showed similar replication kinetics and cytopathogenicity when compared with the corresponding parental proviral clone.

Original language	English
Pages (from-to)	3205-3208
Number of pages	4
Journal	Journal of virology
Volume	63
Issue number	7
DOIs	https://doi.org/10.1128/jvi.63.7.3205-3208.1989
State	Published - 1989

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10.1128/jvi.63.7.3205-3208.1989

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title = "Viral protein R of human immunodeficiency virus types 1 and 2 is dispensable for replication and cytopathogenicity in lymphoid cells",

abstract = "Viral protein R (VPR) is conserved in human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2). To assess its function, we have constructed mutations within the vpr coding regions of HIV-1 and HIV-2 predicted to express truncated VPR products. Infectious virus was produced by each proviral clone and showed similar replication kinetics and cytopathogenicity when compared with the corresponding parental proviral clone.",

author = "D. Dedera and W. Hu and {Vander Heyden}, N. and L. Ratner",

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T1 - Viral protein R of human immunodeficiency virus types 1 and 2 is dispensable for replication and cytopathogenicity in lymphoid cells

AU - Dedera, D.

AU - Hu, W.

AU - Vander Heyden, N.

AU - Ratner, L.

PY - 1989

Y1 - 1989

N2 - Viral protein R (VPR) is conserved in human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2). To assess its function, we have constructed mutations within the vpr coding regions of HIV-1 and HIV-2 predicted to express truncated VPR products. Infectious virus was produced by each proviral clone and showed similar replication kinetics and cytopathogenicity when compared with the corresponding parental proviral clone.

AB - Viral protein R (VPR) is conserved in human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2). To assess its function, we have constructed mutations within the vpr coding regions of HIV-1 and HIV-2 predicted to express truncated VPR products. Infectious virus was produced by each proviral clone and showed similar replication kinetics and cytopathogenicity when compared with the corresponding parental proviral clone.

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U2 - 10.1128/jvi.63.7.3205-3208.1989

DO - 10.1128/jvi.63.7.3205-3208.1989

M3 - Article

C2 - 2524599

AN - SCOPUS:0024359636

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ER -

Viral protein R of human immunodeficiency virus types 1 and 2 is dispensable for replication and cytopathogenicity in lymphoid cells

Abstract

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