Viral protein R of human immunodeficiency virus types 1 and 2 is dispensable for replication and cytopathogenicity in lymphoid cells

D. Dedera, W. Hu, N. Vander Heyden, L. Ratner

Research output: Contribution to journalArticle

78 Scopus citations

Abstract

Viral protein R (VPR) is conserved in human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2). To assess its function, we have constructed mutations within the vpr coding regions of HIV-1 and HIV-2 predicted to express truncated VPR products. Infectious virus was produced by each proviral clone and showed similar replication kinetics and cytopathogenicity when compared with the corresponding parental proviral clone.

Original languageEnglish
Pages (from-to)3205-3208
Number of pages4
JournalJournal of virology
Volume63
Issue number7
StatePublished - Jan 1 1989

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