TY - JOUR
T1 - Viral prevalence by gestational age and season in a large neonatal cord blood cohort
AU - Sloan, Patrick E.
AU - Rodriguez, Cynthia
AU - Holtz, Lori R.
N1 - Funding Information:
This work was supported in part by Doris Duke Charitable Foundation [2017076] and March of Dimes [BOC 388999].
Publisher Copyright:
© 2021 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2022
Y1 - 2022
N2 - Objective: To investigate viral prevalence in a large neonatal cohort and determine the impact on pregnancy and birth outcomes. Study design: We prospectively collected 1044 neonatal samples from remnant neonatal cord blood RPR samples. We performed qRT-PCR/qPCR reactions for: adenovirus, anellovirus (alphatorquevirus and betatorquevirus), cytomegalovirus (CMV), Epstein-Barr virus (EBV), enterovirus, human herpesvirus 6 (HHV6), parechovirus, and parvovirus B19. Result: Overall viral prevalence was 5.6% with 58 positive samples. Alphatorquevirus (2%) and HHV6 (1.2%) were the two most prevalent viruses detected. Viral detection was most common in samples collected in the fall (September-November) and least common in those collected in winter (December–February). There was no statistical difference detected in viral prevalence or viral load by gestational age, preterm delivery, pre-eclampsia or chorioamnionitis. Conclusion: While there is seasonal variation in viral prevalence in neonatal cord blood samples, individual virus presence does not seem to effect pregnancy or birth outcomes.
AB - Objective: To investigate viral prevalence in a large neonatal cohort and determine the impact on pregnancy and birth outcomes. Study design: We prospectively collected 1044 neonatal samples from remnant neonatal cord blood RPR samples. We performed qRT-PCR/qPCR reactions for: adenovirus, anellovirus (alphatorquevirus and betatorquevirus), cytomegalovirus (CMV), Epstein-Barr virus (EBV), enterovirus, human herpesvirus 6 (HHV6), parechovirus, and parvovirus B19. Result: Overall viral prevalence was 5.6% with 58 positive samples. Alphatorquevirus (2%) and HHV6 (1.2%) were the two most prevalent viruses detected. Viral detection was most common in samples collected in the fall (September-November) and least common in those collected in winter (December–February). There was no statistical difference detected in viral prevalence or viral load by gestational age, preterm delivery, pre-eclampsia or chorioamnionitis. Conclusion: While there is seasonal variation in viral prevalence in neonatal cord blood samples, individual virus presence does not seem to effect pregnancy or birth outcomes.
KW - Virus
KW - cord blood
KW - maternal transmission
KW - neonate
KW - viral prevalence
UR - http://www.scopus.com/inward/record.url?scp=85116039323&partnerID=8YFLogxK
U2 - 10.1080/14767058.2021.1983537
DO - 10.1080/14767058.2021.1983537
M3 - Article
C2 - 34587860
AN - SCOPUS:85116039323
SN - 1476-7058
VL - 35
SP - 8482
EP - 8487
JO - Journal of Maternal-Fetal and Neonatal Medicine
JF - Journal of Maternal-Fetal and Neonatal Medicine
IS - 25
ER -