Viral prevalence by gestational age and season in a large neonatal cord blood cohort

Patrick E. Sloan, Cynthia Rodriguez, Lori R. Holtz

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Objective: To investigate viral prevalence in a large neonatal cohort and determine the impact on pregnancy and birth outcomes. Study design: We prospectively collected 1044 neonatal samples from remnant neonatal cord blood RPR samples. We performed qRT-PCR/qPCR reactions for: adenovirus, anellovirus (alphatorquevirus and betatorquevirus), cytomegalovirus (CMV), Epstein-Barr virus (EBV), enterovirus, human herpesvirus 6 (HHV6), parechovirus, and parvovirus B19. Result: Overall viral prevalence was 5.6% with 58 positive samples. Alphatorquevirus (2%) and HHV6 (1.2%) were the two most prevalent viruses detected. Viral detection was most common in samples collected in the fall (September-November) and least common in those collected in winter (December–February). There was no statistical difference detected in viral prevalence or viral load by gestational age, preterm delivery, pre-eclampsia or chorioamnionitis. Conclusion: While there is seasonal variation in viral prevalence in neonatal cord blood samples, individual virus presence does not seem to effect pregnancy or birth outcomes.

Original languageEnglish
JournalJournal of Maternal-Fetal and Neonatal Medicine
StateAccepted/In press - 2021


  • cord blood
  • maternal transmission
  • neonate
  • viral prevalence
  • Virus


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