Viral MHC class I inhibition evades CD8+ T-cell effector responses in vivo but not CD8+ T-cell priming

Maria D. Gainey, Joshua G. Rivenbark, Hyelim Cho, Liping Yang, Wayne M. Yokoyama

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Although viral MHC class I inhibition is considered a classic immune-evasion strategy, its in vivo role is largely unclear. Mutant cowpox virus lacking its MHC class I inhibitors is markedly attenuated during acute infection because of CD8+ T-cell-dependent control, but it was not known how CD8+ T-cell responses are affected. Interestingly, we found no major effect of MHC class I downregulation on priming of functional cowpox virus-specific CD8+T cells. Instead, we demonstrate that, during acute infection in vivo, MHC class I down-regulation prevents primed virus-specific CD8+ T cells from recognizing infected cells and exerting effector responses to control the infection.

Original languageEnglish
Pages (from-to)E3260-E3267
JournalProceedings of the National Academy of Sciences of the United States of America
Volume109
Issue number47
DOIs
StatePublished - Nov 20 2012

Keywords

  • Immune response
  • Orthopoxvirus
  • Virus evasion

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