Video-EEG monitoring methods for characterizing rodent models of tuberous sclerosis and epilepsy

Nicholas R. Rensing, Dongjun Guo, Michael Wong

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations

Abstract

Tuberous Sclerosis Complex (TSC) is a genetic disease involving dysregulation of the mTOR pathway and resulting in disabling neurological manifestations, such as epilepsy. Animal models may recapitulate epilepsy and other behavioral features of TSC and are useful tools for investigating mechanisms of epileptogenesis and other neurological deficits in TSC. In this chapter, methods for performing video-electroencephalography (video-EEG) to characterize epilepsy and neurological dysfunction in rodent models are reviewed. In particular, technical aspects of surgical implantation of EEG electrodes, video-EEG recording, and analysis and interpretation of EEG data are detailed. These methodological approaches should be helpful in characterizing seizures and background EEG abnormalities not only in animal models of TSC but also in many rodent epilepsy models in general.

Original languageEnglish
Title of host publicationmTOR
Subtitle of host publicationMethods and Protocols
EditorsThomas Weichhart
Pages373-391
Number of pages19
DOIs
StatePublished - Jan 2 2012

Publication series

NameMethods in Molecular Biology
Volume821
ISSN (Print)1064-3745

Keywords

  • Electroencephalography
  • Epileptiform
  • Mice
  • Rat
  • Seizure
  • Telemetry
  • Tuberous sclerosis complex
  • Video-EEG

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    Rensing, N. R., Guo, D., & Wong, M. (2012). Video-EEG monitoring methods for characterizing rodent models of tuberous sclerosis and epilepsy. In T. Weichhart (Ed.), mTOR: Methods and Protocols (pp. 373-391). (Methods in Molecular Biology; Vol. 821). https://doi.org/10.1007/978-1-61779-430-8_24