Abstract
Vibration controlled transient elastography (VCTE) is validated for the evaluation of hepatic fibrosis in different liver diseases. Sickle cell liver disease (SCLD) results from a cumulative hepatic injury and its lifelong and progressive nature raises the need for a non-invasive tool for fibrosis evaluation. Fifty patients, aged between 23 and 59 years with sickle cell disease and suspected SCLD underwent a VCTE followed by a liver biopsy. Biopsies were evaluated for various scores of liver disease that were then correlated to VCTE score. 90% of our patients had an Ishak Fibrosis (IF) score between 0–2 (Group A-minimal to no fibrosis) and 10% of the patients had IF score between 3–6 (Group B-advanced fibrosis). The median Transient Elastography (TE) for patients in Groups A and B was 4·8 kilopascals (kPa) and 17·6 kPa, respectively. A positive correlation was shown between TE and IF score, R = 0·0·68 (P = <0·0001); a positive correlation was also shown with Histology Activity Index fibrosis score, R = 0·64 (P = <0·0001). This study emphasises the need for further studies of non-invasive tools and their utility in liver fibrosis evaluation of patients with SCLD.
Original language | English |
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Pages (from-to) | 117-123 |
Number of pages | 7 |
Journal | British Journal of Haematology |
Volume | 187 |
Issue number | 1 |
DOIs | |
State | Published - Oct 1 2019 |
Keywords
- liver biopsy
- sickle cell disease
- sickle cell hepatopathy
- sickle cell liver disease
- vibration controlled transient elastography