Vestigial expression in the Drosophila embryonic central nervous system

Kirsten A. Guss, Hemlata Mistry, James B. Skeath

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

The Drosophila central nervous system is an excellent model system in which to resolve the genetic and molecular control of neuronal differentiation. Here we show that the wing selector vestigial is expressed in discrete sets of neurons. We track the axonal trajectories of VESTIGIAL-expressing cells in the ventral nerve cord and show that these cells descend from neuroblasts 1-2, 5-1, and 5-6. In addition, along the midline, VESTIGIAL is expressed in ventral unpaired median motorneurons and cells that may descend from the median neuroblast. These studies form the requisite descriptive foundation for functional studies addressing the role of vestigial during interneuron differentiation.

Original languageEnglish
Pages (from-to)2483-2489
Number of pages7
JournalDevelopmental Dynamics
Volume237
Issue number9
DOIs
StatePublished - Sep 2008

Keywords

  • CNS
  • Central nervous system
  • Drosophila
  • Embryo
  • Midline
  • Neuroblast
  • VNC
  • Ventral nerve cord
  • Vestigial

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