TY - JOUR
T1 - Very short-term potentiation of climbing fiber effects on deep cerebellar nuclei neurons by conditioning stimulation of mossy fiber afferents
AU - Gruart, Agnès
AU - Blázquez, Pablo
AU - Pastor, Angel M.
AU - Delgado-García, José M.
PY - 1994/9/1
Y1 - 1994/9/1
N2 - Field potentials induced in deep cerebellar nuclei by the electrical stimulation of contralateral red, pontine and reticularis tegmenti pontis oralis nuclei, the restiform body and the inferior olive were recorded in the alert cat. Recording sites in interpositus and fastigial nuclei were selected with the aid of antidromic field potentials induced by red nucleus and restiform body stimulation, respectively. Pontine and reticularis tegmentipontis oralis nuclei stimulation induced small, but constant amplitude, field potentials consisting of one or two negative waves. Control field potentials induced by inferior olive stimulation consisted of a negative wave at 2-3 ms followed by a late (4-6 ms) positivity. Conditioning stimuli applied to the pontine and reticularis tegmenti pontis oralis nuclei greatly enhanced the amplitude of the inferior olive-evoked synaptic field potential for a time window of about 40 ms. In contrast, inferior olive conditioning stimulation failed to modify the field potentials induced by pontine nuclei stimulation. These facilitatory effects on field potential amplitude showed no long-lasting modifications. The transient modification of inferior olive-induced field potentials could be related to attentional movements made by the animal to natural or electrically-induced sensory cues.
AB - Field potentials induced in deep cerebellar nuclei by the electrical stimulation of contralateral red, pontine and reticularis tegmenti pontis oralis nuclei, the restiform body and the inferior olive were recorded in the alert cat. Recording sites in interpositus and fastigial nuclei were selected with the aid of antidromic field potentials induced by red nucleus and restiform body stimulation, respectively. Pontine and reticularis tegmentipontis oralis nuclei stimulation induced small, but constant amplitude, field potentials consisting of one or two negative waves. Control field potentials induced by inferior olive stimulation consisted of a negative wave at 2-3 ms followed by a late (4-6 ms) positivity. Conditioning stimuli applied to the pontine and reticularis tegmenti pontis oralis nuclei greatly enhanced the amplitude of the inferior olive-evoked synaptic field potential for a time window of about 40 ms. In contrast, inferior olive conditioning stimulation failed to modify the field potentials induced by pontine nuclei stimulation. These facilitatory effects on field potential amplitude showed no long-lasting modifications. The transient modification of inferior olive-induced field potentials could be related to attentional movements made by the animal to natural or electrically-induced sensory cues.
KW - Attentional movements
KW - Cats
KW - Deep cerebellar nuclei
KW - Inferior olive
KW - Pontine nuclei
KW - Very short-term potentiation
UR - http://www.scopus.com/inward/record.url?scp=0028018228&partnerID=8YFLogxK
U2 - 10.1007/BF00243229
DO - 10.1007/BF00243229
M3 - Article
C2 - 7843298
AN - SCOPUS:0028018228
SN - 0014-4819
VL - 101
SP - 173
EP - 177
JO - Experimental Brain Research
JF - Experimental Brain Research
IS - 1
ER -