TY - JOUR
T1 - Very Mild Senile Dementia of the Alzheimer Type
T2 - I. Clinical Assessment
AU - Rubin, Eugene H.
AU - Morris, John C.
AU - Grant, Elizabeth A.
AU - Vendegna, Thomas
PY - 1989/4
Y1 - 1989/4
N2 - We report a longitudinal study of 16 subjects originally enrolled in the Washington University (St Louis, Mo) Memory and Aging Project with Clinical Dementia Rating (CDR) of “questionable” dementia (CDR 0.5). A 0.5 rating was intended to characterize subjects in whom mild cognitive impairment due to senile dementia of the Alzheimer type was suspected but was insufficient in degree to warrant a diagnosis of definite dementia. Over an 84-month follow-up period, 11 of the 16 subjects either had Alzheimer's disease verified post mortem or had clinically progressed to a more advanced CDR stage in which the dementia was clearly evident. These results suggest that the CDR 0.5 stage likely represents the incipient clinical manifestation of Alzheimer's disease and that the majority of subjects with CDR 0.5 have “very mild senile dementia of the Alzheimer type.” Performance on several standard clinical scales was significantly different when comparing a larger sample of controls (n = 83), subjects with CDR 0.5 (n = 41), and subjects with mild senile dementia of the Alzheimer type (score of 1; n = 68).
AB - We report a longitudinal study of 16 subjects originally enrolled in the Washington University (St Louis, Mo) Memory and Aging Project with Clinical Dementia Rating (CDR) of “questionable” dementia (CDR 0.5). A 0.5 rating was intended to characterize subjects in whom mild cognitive impairment due to senile dementia of the Alzheimer type was suspected but was insufficient in degree to warrant a diagnosis of definite dementia. Over an 84-month follow-up period, 11 of the 16 subjects either had Alzheimer's disease verified post mortem or had clinically progressed to a more advanced CDR stage in which the dementia was clearly evident. These results suggest that the CDR 0.5 stage likely represents the incipient clinical manifestation of Alzheimer's disease and that the majority of subjects with CDR 0.5 have “very mild senile dementia of the Alzheimer type.” Performance on several standard clinical scales was significantly different when comparing a larger sample of controls (n = 83), subjects with CDR 0.5 (n = 41), and subjects with mild senile dementia of the Alzheimer type (score of 1; n = 68).
UR - http://www.scopus.com/inward/record.url?scp=0024584541&partnerID=8YFLogxK
U2 - 10.1001/archneur.1989.00520400033016
DO - 10.1001/archneur.1989.00520400033016
M3 - Article
C2 - 2650663
AN - SCOPUS:0024584541
SN - 0003-9942
VL - 46
SP - 379
EP - 382
JO - Archives of neurology
JF - Archives of neurology
IS - 4
ER -