Vertebral augmentation reduces the 12-month mortality and morbidity in patients with osteoporotic vertebral compression fractures

Roberto Luigi Cazzato, Teodora Bellone, Marco Scardapane, Pierre De Marini, Pierre Alexis Autrusseau, Pierre Auloge, Julien Garnon, Jack W. Jennings, Afshin Gangi

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Objectives: To investigate the 12-month all-cause mortality and morbidity in patients with osteoporotic vertebral compression fractures (OVCFs) undergoing vertebroplasty/balloon kyphoplasty (VP/BKP) versus non-surgical management (NSM). Methods: Following a Medline and EMBASE search for English language articles published from 2010 to 2019, 19 studies reporting on mortality and morbidity after VP/BKP in patients with OVCFs were selected. The 12-month timeline was set due to the largest amount of data availability at such time interval. Estimates for each study were reported as odds ratios (OR) along with 95% confidence intervals (CI) and p values. Fixed or random-effects meta-analyses were performed. All tests were based on a two-sided significance level of 0.05. Results: Pooled OR across 5 studies favored VP/BKP over NSM in terms of 12-month all-cause mortality (OR: 0.81 [95% CI: 0.46–1.42]; p =.46). Pooled OR across 11 studies favored VP/BKP over NSM in terms of 12-month all-cause morbidity (OR: 0.64 [95% CI: 0.31–1.30]; p =.25). Sub-analysis of data dealing with 12-month infective morbidity from any origin confirmed the benefit of VP/BKP over NSM (OR: 0.23 [95% CI, 0.02–2.54]; p =.23). Conclusion: Compared to NSM, VP/BKP reduces the 12-month risk of all-cause mortality and morbidity by 19% and 36%, respectively. Moreover, VP/BKP reduces by 77% the 12-month risk of infection from any origin. Key Points: • Compared to non-surgical management, vertebral augmentation reduces the 12-month risk of all-cause mortality by 19% and all-cause morbidity by 36%. • Vertebral augmentation reduces the 12-month risk of infection morbidity from any origin by 77%.

Original languageEnglish
Pages (from-to)8246-8255
Number of pages10
JournalEuropean Radiology
Volume31
Issue number11
DOIs
StatePublished - Nov 2021

Keywords

  • Conservative treatment
  • Kyphoplasty
  • Osteoporosis
  • Spinal fractures
  • Vertebroplasty

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