@inproceedings{bee455a29fdf44aebec5a13fea9caf49,
title = "Ventricular diastolic impedance Z(t): Validation of a new, model-based image processing derived index of global diastolic function",
abstract = "The quest for a noninvasive, global index of left ventricular (LV) diastolic function has not yet been attained. Current echocardiographic methods extract components of diastolic function from selected aspects of transmitral flow velocity, ventricular geometry and wall motion. Diastolic left ventricular pressure P(t) and transmitral flow Q(t) define global diastolic impedance as Z(t) = P(t)/Q(t). Since P(t) requires cardiac catherization, we expressed P(t) via the nonsteady Bernoulli equation using Doppler echocardiographically measurable transmitral flow velocity v(t) and acceleration v = dv/dt. For validation we compared catheterization (invasively) derived Zinv(t) with echo (noninvasively) derived Znoninv(t) and found excellent agreement. We conclude that the echocardiographically determined LV diastolic impedance Znoninv(t) provides a physiologically sound quantitative index of global LV diastolic function. Further development and application in selected clinical groups is in progress.",
author = "Milde, {Jonathan M.} and Sessoms, {Mark W.} and Lisauskas, {Jennifer B.} and Michael Courtois and Jasvindar Singh and Kovacs, {Sandor J.}",
year = "1999",
language = "English",
isbn = "0780356756",
series = "Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings",
publisher = "IEEE",
pages = "234",
booktitle = "Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings",
note = "Proceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS) ; Conference date: 13-10-1999 Through 16-10-1999",
}