Ventral rhizotomy enhances regeneration of uninjured sensory neurons

Keith M. Rich; Eugene M. Johnson

doi:10.1016/0006-8993(85)90292-6

Ventral rhizotomy enhances regeneration of uninjured sensory neurons

Keith M. Rich, Eugene M. Johnson

Department of Neurosurgery

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Uninjured sensory neurons show metabolic and morphologic changes, as well as enhanced regeneration, when exposed to adjacent degenerating ventral root fibers. The release of a neurotrophic factor from the degenerating nerve fibers may be responsible for 'priming' the uninjured neuron and thereby enhancing its response to injury.

Original language	English
Pages (from-to)	182-187
Number of pages	6
Journal	Brain Research
Volume	335
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(85)90292-6
State	Published - May 27 1985

Keywords

axonal regeneration
conditioning lesion
nerve trauma
rat
sciatic nerve
ventral rhizotomy

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10.1016/0006-8993(85)90292-6

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title = "Ventral rhizotomy enhances regeneration of uninjured sensory neurons",

abstract = "Uninjured sensory neurons show metabolic and morphologic changes, as well as enhanced regeneration, when exposed to adjacent degenerating ventral root fibers. The release of a neurotrophic factor from the degenerating nerve fibers may be responsible for 'priming' the uninjured neuron and thereby enhancing its response to injury.",

keywords = "axonal regeneration, conditioning lesion, nerve trauma, rat, sciatic nerve, ventral rhizotomy",

author = "Rich, {Keith M.} and Johnson, {Eugene M.}",

note = "Funding Information: We thank Dr. Henry Yip, Dr. Robert Schmidt, Patricia Osborne, and Pat Lampe for the advice and assistance. We appreciate the use of Dr. Thomas Woolsey's computer facilities. This work was supported by NIH Grants HL20604 and NS18071.",

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AU - Rich, Keith M.

AU - Johnson, Eugene M.

N1 - Funding Information: We thank Dr. Henry Yip, Dr. Robert Schmidt, Patricia Osborne, and Pat Lampe for the advice and assistance. We appreciate the use of Dr. Thomas Woolsey's computer facilities. This work was supported by NIH Grants HL20604 and NS18071.

PY - 1985/5/27

Y1 - 1985/5/27

N2 - Uninjured sensory neurons show metabolic and morphologic changes, as well as enhanced regeneration, when exposed to adjacent degenerating ventral root fibers. The release of a neurotrophic factor from the degenerating nerve fibers may be responsible for 'priming' the uninjured neuron and thereby enhancing its response to injury.

AB - Uninjured sensory neurons show metabolic and morphologic changes, as well as enhanced regeneration, when exposed to adjacent degenerating ventral root fibers. The release of a neurotrophic factor from the degenerating nerve fibers may be responsible for 'priming' the uninjured neuron and thereby enhancing its response to injury.

KW - axonal regeneration

KW - conditioning lesion

KW - nerve trauma

KW - rat

KW - sciatic nerve

KW - ventral rhizotomy

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DO - 10.1016/0006-8993(85)90292-6

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VL - 335

SP - 182

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JO - Brain Research

JF - Brain Research

IS - 1

ER -

Ventral rhizotomy enhances regeneration of uninjured sensory neurons

Abstract

Keywords

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