Ventral arkypallidal neurons inhibit accumbal firing to promote reward consumption

Yvan M. Vachez, Jessica R. Tooley, Kavitha Abiraman, Bridget Matikainen-Ankney, Eric Casey, Tom Earnest, Leana M. Ramos, Hanna Silberberg, Elizabeth Godynyuk, Olivia Uddin, Lauren Marconi, Claire E. Le Pichon, Meaghan C. Creed

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

The nucleus accumbens shell (NAcSh) and the ventral pallidum (VP) are critical for reward processing, although the question of how coordinated activity within these nuclei orchestrates reward valuation and consumption remains unclear. Inhibition of NAcSh firing is necessary for reward consumption, but the source of this inhibition remains unknown. Here, we report that a subpopulation of VP neurons, the ventral arkypallidal (vArky) neurons, project back to the NAcSh, where they inhibit NAcSh neurons in vivo in mice. Consistent with this pathway driving reward consumption via inhibition of the NAcSh, calcium activity of vArky neurons scaled with reward palatability (which was dissociable from reward seeking) and predicted the subsequent drinking behavior during a free-access paradigm. Activation of the VP–NAcSh pathway increased ongoing reward consumption while amplifying hedonic reactions to reward. These results establish a pivotal role for vArky neurons in the promotion of reward consumption through modulation of NAcSh firing in a value-dependent manner.

Original languageEnglish
Pages (from-to)379-390
Number of pages12
JournalNature neuroscience
Volume24
Issue number3
DOIs
StatePublished - Mar 2021

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