TY - JOUR
T1 - Veno-venous extracorporeal membrane oxygenation use in the treatment of bleomycin pulmonary toxicity
AU - Shah, Aakash
AU - Pasrija, Chetan
AU - Kronfli, Anthony
AU - Wehman, Brody
AU - Griffith, Bartley P.
AU - Sanchez, Pablo G.
AU - Garcia, Jose P.
AU - Kon, Zachary N.
N1 - Publisher Copyright:
Copyright © 2017 by the International Society for Minimally Invasive Cardiothoracic Surgery.
PY - 2017
Y1 - 2017
N2 - Pulmonary toxicity is a devastating complication of bleomycin chemotherapy. This insult is likely exacerbated by the free radical injury induced by high inspired oxygen content, which is required to support these patients. Traditional treatment consists of high-dose corticosteroids. We report the case of a 45-year-old man who developed bleomycin pulmonary toxicity, which failed to respond to treatment with highdose corticosteroids. We used protectivemechanical ventilatory settings while supported on veno-venous extracorporeal membrane oxygenation using a bicaval dual-lumen, single cannula systemto allow for lung recovery. This case demonstrates the feasibility of using veno-venous extracorporeal membrane oxygenation to treat bleomycin pulmonary toxicity in a patient who has failed traditional therapy.
AB - Pulmonary toxicity is a devastating complication of bleomycin chemotherapy. This insult is likely exacerbated by the free radical injury induced by high inspired oxygen content, which is required to support these patients. Traditional treatment consists of high-dose corticosteroids. We report the case of a 45-year-old man who developed bleomycin pulmonary toxicity, which failed to respond to treatment with highdose corticosteroids. We used protectivemechanical ventilatory settings while supported on veno-venous extracorporeal membrane oxygenation using a bicaval dual-lumen, single cannula systemto allow for lung recovery. This case demonstrates the feasibility of using veno-venous extracorporeal membrane oxygenation to treat bleomycin pulmonary toxicity in a patient who has failed traditional therapy.
KW - Acute respiratory distress syndrome
KW - Bleomycin toxicity
KW - Extracorporeal membrane oxygenation
UR - http://www.scopus.com/inward/record.url?scp=85010875096&partnerID=8YFLogxK
U2 - 10.1097/IMI.0000000000000340
DO - 10.1097/IMI.0000000000000340
M3 - Article
C2 - 28121640
AN - SCOPUS:85010875096
SN - 1556-9845
VL - 12
SP - 144
EP - 146
JO - Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
JF - Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
IS - 2
ER -