VDJ recombination

Frederick W. Alt; Eugene M. Oltz; Faith Young; James Gorman; Guillermo Taccioli; Jianzhu Chen

doi:10.1016/0167-5699(92)90043-7

VDJ recombination

Frederick W. Alt, Eugene M. Oltz, Faith Young, James Gorman, Guillermo Taccioli, Jianzhu Chen

Division of Laboratory and Genomic Medicine

Research output: Contribution to journal › Review article › peer-review

350 Scopus citations

Abstract

The ability of lymphocyte receptor V, D and J gene segments to rearrange generates much of the receptor diversity that is the hallmark of the immune system. Naturally, the mechanisms of immunoglobulin and T-cell receptor gene recombination are of enormous interest. Here, Fred Alt and colleagues review current understanding of the process and speculate on future findings.

Original language	English
Pages (from-to)	306-314
Number of pages	9
Journal	Immunology today
Volume	13
Issue number	8
DOIs	https://doi.org/10.1016/0167-5699(92)90043-7
State	Published - 1992

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10.1016/0167-5699(92)90043-7

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title = "VDJ recombination",

abstract = "The ability of lymphocyte receptor V, D and J gene segments to rearrange generates much of the receptor diversity that is the hallmark of the immune system. Naturally, the mechanisms of immunoglobulin and T-cell receptor gene recombination are of enormous interest. Here, Fred Alt and colleagues review current understanding of the process and speculate on future findings.",

author = "Alt, {Frederick W.} and Oltz, {Eugene M.} and Faith Young and James Gorman and Guillermo Taccioli and Jianzhu Chen",

year = "1992",

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language = "English",

volume = "13",

pages = "306--314",

journal = "Immunology today",

issn = "0167-5699",

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TY - JOUR

T1 - VDJ recombination

AU - Alt, Frederick W.

AU - Oltz, Eugene M.

AU - Young, Faith

AU - Gorman, James

AU - Taccioli, Guillermo

AU - Chen, Jianzhu

PY - 1992

Y1 - 1992

N2 - The ability of lymphocyte receptor V, D and J gene segments to rearrange generates much of the receptor diversity that is the hallmark of the immune system. Naturally, the mechanisms of immunoglobulin and T-cell receptor gene recombination are of enormous interest. Here, Fred Alt and colleagues review current understanding of the process and speculate on future findings.

AB - The ability of lymphocyte receptor V, D and J gene segments to rearrange generates much of the receptor diversity that is the hallmark of the immune system. Naturally, the mechanisms of immunoglobulin and T-cell receptor gene recombination are of enormous interest. Here, Fred Alt and colleagues review current understanding of the process and speculate on future findings.

UR - http://www.scopus.com/inward/record.url?scp=0026664137&partnerID=8YFLogxK

U2 - 10.1016/0167-5699(92)90043-7

DO - 10.1016/0167-5699(92)90043-7

M3 - Review article

C2 - 1510813

AN - SCOPUS:0026664137

SN - 0167-5699

VL - 13

SP - 306

EP - 314

JO - Immunology today

JF - Immunology today

IS - 8

ER -

VDJ recombination

Abstract

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