VDJ recombination

Frederick W. Alt, Eugene M. Oltz, Faith Young, James Gorman, Guillermo Taccioli, Jianzhu Chen

Research output: Contribution to journalReview articlepeer-review

313 Scopus citations

Abstract

The ability of lymphocyte receptor V, D and J gene segments to rearrange generates much of the receptor diversity that is the hallmark of the immune system. Naturally, the mechanisms of immunoglobulin and T-cell receptor gene recombination are of enormous interest. Here, Fred Alt and colleagues review current understanding of the process and speculate on future findings.

Original languageEnglish
Pages (from-to)306-314
Number of pages9
JournalImmunology today
Volume13
Issue number8
DOIs
StatePublished - 1992

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