Vasculogenesis in Development

S. C. Chetty; K. Choi; S. Sumanas

doi:10.1016/B978-0-12-809657-4.99545-0

Vasculogenesis in Development

S. C. Chetty, K. Choi, S. Sumanas

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

The vascular system is one of the earliest functional organ systems to develop in a vertebrate embryo. The major blood vessels form by the mechanism of vasculogenesis which involves differentiation of mesodermal cells into vascular endothelial progenitors. Here we overview the current knowledge on the cellular and molecular mechanisms that regulate vasculogenesis, including specification of vascular progenitors, their migration and colaescence into primordial vessels, arteriovenous differentiation, and lumen formation.

Original language	English
Title of host publication	Encyclopedia of Cardiovascular Research and Medicine
Publisher	Elsevier
Pages	640-653
Number of pages	14
Volume	1-4
ISBN (Electronic)	9780128051542
ISBN (Print)	9780128096574
DOIs	https://doi.org/10.1016/B978-0-12-809657-4.99545-0
State	Published - Jan 1 2017

Keywords

Angioblasts
Arterial
Embryonic development
Endothelial
Etv2
Lumen
VEGF
Vascular
Vasculogenesis
Venous

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10.1016/B978-0-12-809657-4.99545-0

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abstract = "The vascular system is one of the earliest functional organ systems to develop in a vertebrate embryo. The major blood vessels form by the mechanism of vasculogenesis which involves differentiation of mesodermal cells into vascular endothelial progenitors. Here we overview the current knowledge on the cellular and molecular mechanisms that regulate vasculogenesis, including specification of vascular progenitors, their migration and colaescence into primordial vessels, arteriovenous differentiation, and lumen formation.",

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AU - Choi, K.

AU - Sumanas, S.

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AB - The vascular system is one of the earliest functional organ systems to develop in a vertebrate embryo. The major blood vessels form by the mechanism of vasculogenesis which involves differentiation of mesodermal cells into vascular endothelial progenitors. Here we overview the current knowledge on the cellular and molecular mechanisms that regulate vasculogenesis, including specification of vascular progenitors, their migration and colaescence into primordial vessels, arteriovenous differentiation, and lumen formation.

KW - Angioblasts

KW - Arterial

KW - Embryonic development

KW - Endothelial

KW - Etv2

KW - Lumen

KW - VEGF

KW - Vascular

KW - Vasculogenesis

KW - Venous

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M3 - Chapter

AN - SCOPUS:85159011000

SN - 9780128096574

VL - 1-4

SP - 640

EP - 653

BT - Encyclopedia of Cardiovascular Research and Medicine

PB - Elsevier

ER -

Vasculogenesis in Development

Abstract

Keywords

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