TY - JOUR
T1 - Vascular elastic fiber heterogeneity in health and disease
AU - Halabi, Carmen M.
AU - Kozel, Beth A.
N1 - Funding Information:
B.A.K. was supported by funding from the NHLBI Division of Intramural Research. C.M.H. was supported by NIH grant K08HL135400.
Publisher Copyright:
© 2020 Lippincott Williams and Wilkins. All rights reserved.
PY - 2020/5/1
Y1 - 2020/5/1
N2 - Purpose of reviewElastin has historically been described as an amorphous protein that functions to provide recoil to tissues that stretch. However, evidence is growing that elastin's role may not be limited to biomechanics. In this minireview, we will summarize current knowledge regarding vascular elastic fibers, focusing on structural differences along the arterial tree and how those differences may influence the behavior of affiliated cells.Recent findingsRegional heterogeneity, including differences in elastic lamellar number, density and cell developmental origin, plays an important role in vessel health and function. These differences impact cell-cell communication, proliferation and movement. Perturbations of normal cell-matrix interactions are correlated with human diseases including aneurysm, atherosclerosis and hypertension.SummaryAlthough classically described as a structural protein, recent data suggest that differences in elastin deposition along the arterial tree have important effects on heterotypic cell interactions and human disease.
AB - Purpose of reviewElastin has historically been described as an amorphous protein that functions to provide recoil to tissues that stretch. However, evidence is growing that elastin's role may not be limited to biomechanics. In this minireview, we will summarize current knowledge regarding vascular elastic fibers, focusing on structural differences along the arterial tree and how those differences may influence the behavior of affiliated cells.Recent findingsRegional heterogeneity, including differences in elastic lamellar number, density and cell developmental origin, plays an important role in vessel health and function. These differences impact cell-cell communication, proliferation and movement. Perturbations of normal cell-matrix interactions are correlated with human diseases including aneurysm, atherosclerosis and hypertension.SummaryAlthough classically described as a structural protein, recent data suggest that differences in elastin deposition along the arterial tree have important effects on heterotypic cell interactions and human disease.
KW - elastic fibers
KW - elastin
KW - endothelial cells
KW - smooth muscle cells
UR - http://www.scopus.com/inward/record.url?scp=85082780355&partnerID=8YFLogxK
U2 - 10.1097/MOH.0000000000000578
DO - 10.1097/MOH.0000000000000578
M3 - Review article
C2 - 32141894
AN - SCOPUS:85082780355
SN - 1065-6251
VL - 27
SP - 190
EP - 196
JO - Current opinion in hematology
JF - Current opinion in hematology
IS - 3
ER -