Linkage studies indicate that the same region of chromosome 10 contains a risk locus for late onset Alzheimer disease (LOAD) and a QTL for plasma Aβ42 levels suggesting that a single locus may influence risk for AD by elevating plasma Aβ42 [Ertekin-Taner et al., 2000; Myers et al., 2000]. A strong positional and biological candidate is the urokinase-plasminogen activator (PLAU) gene. Eight polymorphisms spanning the entire gene were examined using case control (CC) and family-based association methods. No association was observed by any method making it unlikely that variation in PLAU explains our linkage data.
|Number of pages||9|
|Journal||American Journal of Medical Genetics - Neuropsychiatric Genetics|
|State||Published - Jan 1 2004|
- Alzheimer disease
- Association study
- Candidate gene
- Urokinase-plasminogen activator