Variation in the Urokinase-Plasminogen Activator Gene Does Not Explain the Chromosome 10 Linkage Signal for Late Onset AD

Amanda J. Myers; Helen Marshall; Peter Holmans; Danielle Compton; Richard J.P. Crook; Adrian P. Mander; Petra Nowotny; Scott Smemo; Melanie Dunstan; Luke Jehu; Jen C. Wang; Marian Hamshere; John C. Morris; Joanne Norton; Sumi Chakraventy; Nigel Tunstall; Simon Lovestone; Ronald Petersen; Michael O'Donovan; Lesley Jones; Julie Williams; Michael J. Owen; John Hardy; Alison Goate

doi:10.1002/ajmg.b.20036

Variation in the Urokinase-Plasminogen Activator Gene Does Not Explain the Chromosome 10 Linkage Signal for Late Onset AD

Amanda J. Myers, Helen Marshall, Peter Holmans, Danielle Compton, Richard J.P. Crook, Adrian P. Mander, Petra Nowotny, Scott Smemo, Melanie Dunstan, Luke Jehu, Jen C. Wang, Marian Hamshere, John C. Morris, Joanne Norton, Sumi Chakraventy, Nigel Tunstall, Simon Lovestone, Ronald Petersen, Michael O'Donovan, Lesley JonesJulie Williams, Michael J. Owen, John Hardy, Alison Goate

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Abstract

Linkage studies indicate that the same region of chromosome 10 contains a risk locus for late onset Alzheimer disease (LOAD) and a QTL for plasma Aβ42 levels suggesting that a single locus may influence risk for AD by elevating plasma Aβ42 [Ertekin-Taner et al., 2000; Myers et al., 2000]. A strong positional and biological candidate is the urokinase-plasminogen activator (PLAU) gene. Eight polymorphisms spanning the entire gene were examined using case control (CC) and family-based association methods. No association was observed by any method making it unlikely that variation in PLAU explains our linkage data.

Original language	English
Pages (from-to)	29-37
Number of pages	9
Journal	American Journal of Medical Genetics - Neuropsychiatric Genetics
Volume	124 B
Issue number	1
DOIs	https://doi.org/10.1002/ajmg.b.20036
State	Published - Jan 1 2004

Keywords

Alzheimer disease
Association study
Candidate gene
PLAU
Urokinase-plasminogen activator

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Myers, A. J., Marshall, H., Holmans, P., Compton, D., Crook, R. J. P., Mander, A. P., Nowotny, P., Smemo, S., Dunstan, M., Jehu, L., Wang, J. C., Hamshere, M., Morris, J. C., Norton, J., Chakraventy, S., Tunstall, N., Lovestone, S., Petersen, R., O'Donovan, M., ... Goate, A. (2004). Variation in the Urokinase-Plasminogen Activator Gene Does Not Explain the Chromosome 10 Linkage Signal for Late Onset AD. American Journal of Medical Genetics - Neuropsychiatric Genetics, 124 B(1), 29-37. https://doi.org/10.1002/ajmg.b.20036

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title = "Variation in the Urokinase-Plasminogen Activator Gene Does Not Explain the Chromosome 10 Linkage Signal for Late Onset AD",

abstract = "Linkage studies indicate that the same region of chromosome 10 contains a risk locus for late onset Alzheimer disease (LOAD) and a QTL for plasma Aβ42 levels suggesting that a single locus may influence risk for AD by elevating plasma Aβ42 [Ertekin-Taner et al., 2000; Myers et al., 2000]. A strong positional and biological candidate is the urokinase-plasminogen activator (PLAU) gene. Eight polymorphisms spanning the entire gene were examined using case control (CC) and family-based association methods. No association was observed by any method making it unlikely that variation in PLAU explains our linkage data.",

keywords = "Alzheimer disease, Association study, Candidate gene, PLAU, Urokinase-plasminogen activator",

author = "Myers, {Amanda J.} and Helen Marshall and Peter Holmans and Danielle Compton and Crook, {Richard J.P.} and Mander, {Adrian P.} and Petra Nowotny and Scott Smemo and Melanie Dunstan and Luke Jehu and Wang, {Jen C.} and Marian Hamshere and Morris, {John C.} and Joanne Norton and Sumi Chakraventy and Nigel Tunstall and Simon Lovestone and Ronald Petersen and Michael O'Donovan and Lesley Jones and Julie Williams and Owen, {Michael J.} and John Hardy and Alison Goate",

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doi = "10.1002/ajmg.b.20036",

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Myers, AJ, Marshall, H, Holmans, P, Compton, D, Crook, RJP, Mander, AP, Nowotny, P, Smemo, S, Dunstan, M, Jehu, L, Wang, JC, Hamshere, M, Morris, JC, Norton, J, Chakraventy, S, Tunstall, N, Lovestone, S, Petersen, R, O'Donovan, M, Jones, L, Williams, J, Owen, MJ, Hardy, J & Goate, A 2004, 'Variation in the Urokinase-Plasminogen Activator Gene Does Not Explain the Chromosome 10 Linkage Signal for Late Onset AD', American Journal of Medical Genetics - Neuropsychiatric Genetics, vol. 124 B, no. 1, pp. 29-37. https://doi.org/10.1002/ajmg.b.20036

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AU - Myers, Amanda J.

AU - Marshall, Helen

AU - Holmans, Peter

AU - Compton, Danielle

AU - Crook, Richard J.P.

AU - Mander, Adrian P.

AU - Nowotny, Petra

AU - Smemo, Scott

AU - Dunstan, Melanie

AU - Jehu, Luke

AU - Wang, Jen C.

AU - Hamshere, Marian

AU - Morris, John C.

AU - Norton, Joanne

AU - Chakraventy, Sumi

AU - Tunstall, Nigel

AU - Lovestone, Simon

AU - Petersen, Ronald

AU - O'Donovan, Michael

AU - Jones, Lesley

AU - Williams, Julie

AU - Owen, Michael J.

AU - Hardy, John

AU - Goate, Alison

PY - 2004/1/1

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AB - Linkage studies indicate that the same region of chromosome 10 contains a risk locus for late onset Alzheimer disease (LOAD) and a QTL for plasma Aβ42 levels suggesting that a single locus may influence risk for AD by elevating plasma Aβ42 [Ertekin-Taner et al., 2000; Myers et al., 2000]. A strong positional and biological candidate is the urokinase-plasminogen activator (PLAU) gene. Eight polymorphisms spanning the entire gene were examined using case control (CC) and family-based association methods. No association was observed by any method making it unlikely that variation in PLAU explains our linkage data.

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Variation in the Urokinase-Plasminogen Activator Gene Does Not Explain the Chromosome 10 Linkage Signal for Late Onset AD

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Keywords

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