TY - JOUR
T1 - Variation in Phenotype Definitions in Observational Clinical Research
T2 - A Review of Three Conditions
AU - Shoaibi, Azza
AU - Ostropolets, Anna
AU - Weaver, James
AU - Rao, Gowtham A.
AU - Golozar, Asieh
AU - Swerdel, Joel
AU - Huser, Vojtech
AU - Adam, Atif
AU - Alshammari, Thamir
AU - Anikpezie, Nnabuchi
AU - Baumgartner, William A.
AU - Brand, Milou
AU - Fan, Ruochong
AU - Kanter, Andrew S.
AU - Kern, Dave
AU - Melisa, Septi
AU - Minty, Evan
AU - Mo, Jessica
AU - Oluwalade, Bolu
AU - Schilling, Lisa M.
AU - Spence, Hayden
AU - Stocking, Jacqueline C.
AU - Zhang, Linying
AU - Ryan, Patrick
N1 - Publisher Copyright:
©2024 AMIA - All rights reserved.
PY - 2024
Y1 - 2024
N2 - Our study examined the heterogeneity of phenotype algorithms (PA) in literature on Alzheimer's disease (AD), major depressive disorder (MDD), and pulmonary arterial hypertension (PAI), focusing on the impact of PA differences on patient overlap and incidence rate variability across conditions in six observational databases. We reviewed 49 replicated PAs (13 for AD, 23 for MDD, and 13 for PAI) and found significant heterogeneity. These varied PAs identified distinct patient cohorts, resulting in significant incidence rate heterogeneity. Despite some papers reporting primary condition codes and inclusion. comprehensive documentation ensuring reproducibility was often lacking, underscoring the need for more transparent and robust research practices.
AB - Our study examined the heterogeneity of phenotype algorithms (PA) in literature on Alzheimer's disease (AD), major depressive disorder (MDD), and pulmonary arterial hypertension (PAI), focusing on the impact of PA differences on patient overlap and incidence rate variability across conditions in six observational databases. We reviewed 49 replicated PAs (13 for AD, 23 for MDD, and 13 for PAI) and found significant heterogeneity. These varied PAs identified distinct patient cohorts, resulting in significant incidence rate heterogeneity. Despite some papers reporting primary condition codes and inclusion. comprehensive documentation ensuring reproducibility was often lacking, underscoring the need for more transparent and robust research practices.
UR - https://www.scopus.com/pages/publications/105006857035
M3 - Review article
C2 - 40417462
AN - SCOPUS:105006857035
SN - 1559-4076
VL - 2024
SP - 1021
EP - 1029
JO - AMIA ... Annual Symposium proceedings. AMIA Symposium
JF - AMIA ... Annual Symposium proceedings. AMIA Symposium
ER -