@article{5cc17989fb0e4542bf40c45de003df4c,
title = "Variants near CHRNB3-CHRNA6 are associated with DSM-5 cocaine use disorder: Evidence for pleiotropy",
abstract = "In the U.S.A., cocaine is the second most abused illicit drug. Variants within the CHRNB3-A6 gene cluster have been associated with cigarette consumption in several GWAS. These receptors represent intriguing candidates for the study of cocaine dependence because nicotinic receptors are thought to be involved in generalized addiction pathways. Using genotypic data from a GWAS of the Study of Addiction: Genetics and Environment (SAGE) dataset, we tested for association of CHRNB3-A6 SNPs with DSM-5 cocaine use disorder. Multiple SNPs in the region were significantly associated with increased risk of cocaine use disorder. Inclusion of the most significant SNP as a covariate in a linear regression model provided evidence for an additional independent signal within this locus for cocaine use disorder. These results suggest that the CHRNB3-A6 locus contains multiple variants affecting risk for vulnerability to cocaine and nicotine dependence as well as bipolar disorder, suggesting that they have pleiotropic effects.",
author = "Brooke Sadler and Gabe Haller and Arpana Agrawal and Rob Culverhouse and Kathleen Bucholz and Andy Brooks and Jay Tischfield and Johnson, {Eric O.} and Howard Edenberg and Marc Schuckit and Nancy Saccone and Laura Bierut and Alison Goate",
note = "Funding Information: The Collaborative Study on the Genetics of Alcoholism (COGA): COGA, Principal Investigators B Porjesz, V Hesselbrock, H Edenberg, L Bierut includes ten different centers: University of Connecticut (V Hesselbrock); Indiana University (HJ Edenberg, J Nurnberger Jr, T Foroud); University of Iowa (S Kuperman, J Kramer); SUNY Downstate (B Porjesz); Washington University in Saint Louis (L Bierut, A Goate, J Rice, K Bucholz); University of California at San Diego (M Schuckit); Rutgers University (J Tischfield); Southwest Foundation (L Almasy), Howard University (R Taylor) and Virginia Commonwealth University (D Dick). A Parsian and M Reilly are the NIAAA Staff Collaborators. We continue to be inspired by our memories of Henri Begleiter and Theodore Reich, founding PI and Co-PI of COGA, and also owe a debt of gratitude to other past organizers of COGA, including Ting-Kai Li, currently a consultant with COGA, P Michael Conneally, Raymond Crowe and Wendy Reich, for their critical contributions. In memory of Theodore Reich, founding Principal Investigator of COGEND, we are indebted to his leadership in the establishment and nurturing of COGEND and acknowledge with great admiration his seminal scientific contributions to the field. Lead investigators directing data collection for COGEND are Laura Bierut, Naomi Breslau, Dorothy Hatsukami, and Eric Johnson. The authors thank Heidi Kromrei and Tracey Richmond for their assistance in COGEND data collection. COGA is a national collaborative study supported by NIH Grant U10AA008401 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) and the National Institute on Drug Abuse (NIDA). COGEND is a collaborative research group and part of the National Institute on Drug Abuse (NIDA) Genetics Consortium. Subject collection was supported by NIH grant P01 CA89392 (PI - L Bierut) from the NCI. Phenotypic and genotypic data are stored in the NIDA Center for Genetic Studies (NCGS) at http://zork. wustl.edu/ under NIDA Contract HHSN271200477451C (PIs J Tischfield and J Rice).",
year = "2014",
month = mar,
day = "28",
doi = "10.1038/srep04497",
language = "English",
volume = "4",
journal = "Scientific reports",
issn = "2045-2322",
}