TY - JOUR
T1 - Variant in a common odorant-binding protein gene is associated with bitter sensitivity in people
AU - Tomassini Barbarossa, Iole
AU - Ozdener, M. Hakan
AU - Melania,
AU - Love-Gregory, Latisha
AU - Mitreva, Makedonka
AU - Abumrad, Nada A.
AU - Pepino, M. Yanina
N1 - Publisher Copyright:
© 2017 Elsevier B.V.
PY - 2017/6/30
Y1 - 2017/6/30
N2 - Deeper understanding of signaling mechanisms underlying bitterness perception in people is essential for designing novel and effective bitter blockers, which could enhance nutrition and compliance with orally administered bitter-tasting drugs. Here we show that variability in a human odorant-binding protein gene, OBPIIa, associates with individual differences in bitterness perception of fat (oleic acid) and of a prototypical bitter stimulus, 6-n-propylthiouracil (PROP), suggesting a novel olfactory role in the modulation of bitterness sensitivity.
AB - Deeper understanding of signaling mechanisms underlying bitterness perception in people is essential for designing novel and effective bitter blockers, which could enhance nutrition and compliance with orally administered bitter-tasting drugs. Here we show that variability in a human odorant-binding protein gene, OBPIIa, associates with individual differences in bitterness perception of fat (oleic acid) and of a prototypical bitter stimulus, 6-n-propylthiouracil (PROP), suggesting a novel olfactory role in the modulation of bitterness sensitivity.
KW - Bitter taste
KW - Individual differences
KW - Olfaction
KW - Olfactory binding protein
KW - PROP
KW - Smell
UR - http://www.scopus.com/inward/record.url?scp=85018923117&partnerID=8YFLogxK
U2 - 10.1016/j.bbr.2017.05.015
DO - 10.1016/j.bbr.2017.05.015
M3 - Article
C2 - 28487220
AN - SCOPUS:85018923117
SN - 0166-4328
VL - 329
SP - 200
EP - 204
JO - Behavioural Brain Research
JF - Behavioural Brain Research
ER -