Deeper understanding of signaling mechanisms underlying bitterness perception in people is essential for designing novel and effective bitter blockers, which could enhance nutrition and compliance with orally administered bitter-tasting drugs. Here we show that variability in a human odorant-binding protein gene, OBPIIa, associates with individual differences in bitterness perception of fat (oleic acid) and of a prototypical bitter stimulus, 6-n-propylthiouracil (PROP), suggesting a novel olfactory role in the modulation of bitterness sensitivity.

Original languageEnglish
Pages (from-to)200-204
Number of pages5
JournalBehavioural Brain Research
StatePublished - Jun 30 2017


  • Bitter taste
  • Individual differences
  • Olfaction
  • Olfactory binding protein
  • PROP
  • Smell


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