Variable Potency of Intramuscular Vitamin D Preparations

Michael P. Whyte, John G. Haddad, Desmond D. Walters, Trevor C.B. Stamp

Research output: Contribution to journalLetterpeer-review

5 Scopus citations


To the Editor: Depot administration of vitamin D by intramuscular injection is an accepted alternative for prophylaxis or therapy when oral dosing is unsuccessful.1 Although two intramuscular preparations (calciferol and Vitadee) are sold in the United States, intravenous preparations of vitamin D are not available commercially. When one of our patients with gastrointestinal malabsorption, hypocalcemia, recurrent tetany and subnormal serum 25-hydroxyvitamin D levels (4 ng per milliliter — normal, >8) failed to show increased serum 25-hydroxyvitamin D concentrations after an intramuscular injection of calciferol, we investigated the vitamin D content of several parenteral preparations available from our hospital pharmacies. Vitamin.

Original languageEnglish
Number of pages1
JournalNew England Journal of Medicine
Issue number3
StatePublished - Jan 18 1979


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