Variable Association of Physiologic Changes With Electrographic Seizure-Like Events in Infants Born Preterm

Stephanie S. Lee, Nathalie El Ters, Zachary A. Vesoulis, John M. Zempel, Amit M. Mathur

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Objectives: To determine the incidence of seizure-like events in a cohort of infants born preterm as well as the prevalence of associated vital sign changes (heart rate [HR], respiratory rate, and pulse oximetry [SpO2]). Study design: We performed prospective conventional video electroencephalogram monitoring on infants born at 23-30 weeks of gestational age during the first 4 postnatal days. For detected seizure-like events, simultaneously captured vital sign data were analyzed during the pre-event baseline and during the event. Significant vital sign changes were defined as HR or respiratory rate >±2 SD from the infant's own baseline physiologic mean, derived from a 10-minute interval before the seizure-like event. Significant change in SpO2 was defined as oxygen desaturation during the event with a mean SpO2 <88%. Results: Our sample included 48 infants with median gestational age of 28 weeks (IQR 26-29) and birth weight of 1125 g (IQR 963-1265). Twelve (25%) infants had seizure-like discharges with a total of 201 events; 83% (10/12) of infants had vital sign changes during these events, and 50% (6/12) had significant vital sign changes during the majority of the seizure-like events. Concurrent HR changes occurred the most frequently. Conclusions: Individual infant variability was observed in the prevalence of concurrent vital sign changes with electroencephalographic seizure-like events. Physiologic changes associated with preterm electrographic seizure-like events should be investigated further as a potential biomarker to assess the clinical significance of such events in the preterm population.

Original languageEnglish
Article number113348
JournalJournal of Pediatrics
StatePublished - Jun 2023


  • premature
  • video EEG
  • vital signs


Dive into the research topics of 'Variable Association of Physiologic Changes With Electrographic Seizure-Like Events in Infants Born Preterm'. Together they form a unique fingerprint.

Cite this