Variability of human linkage data

D. C. Rao, B. J.B. Keats, N. E. Morton, S. Yee, R. Lew

Research output: Contribution to journalArticlepeer-review

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Abstract

Linkage scores (lods) are reduced to a standard table for 1,665 pairs of loci. The likelihood ratio test of homogeneity is shown to be conservative in these small samples; for theta <.5 the nominal significance level of .05 corresponds to a true significance level of .026. Sex is the major cause of variability for linked loci. Biological and technical sources of residual heterogeneity are discussed and illustrated by published examples. Empirical power and reliability are in good agreement with earlier predictions.

Original languageEnglish
Pages (from-to)516-529
Number of pages14
JournalAmerican journal of human genetics
Volume30
Issue number5
StatePublished - 1978

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