Variability in annual mini-mental state examination score in patients with probable Alzheimer disease: A clinical perspective of data from the consortium to establish a registry for Alzheimer's disease

Christopher M. Clark, Lianne Sheppard, Gerda G. Fillenbaum, Douglas Galasko, John C. Morris, Elizabeth Koss, Richard Mohs, Albert Heyman

Research output: Contribution to journalArticlepeer-review

219 Scopus citations

Abstract

Objective: To determine the variability in annual Mini-Mental State Examination scores of patients with Alzheimer disease enrolled in the Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Patients: A total of 372 patients with probable Alzheimer disease with 1 or more years of follow-up. Setting: Twenty-one CERAD clinical sites throughout the United States. Results: An average annual decline of 3.4 points in CERAD patients returning for longitudinal reassessments was close to the SD of the measurement error of 2.8 points for the Mini-Mental State Examination. There was wide variability in individual rates of decline. Even with 4 years of follow-up, 15.8% of the patients had no clinically meaningful decline in Mini-Mental State Examination score (defined as a change in initial score >3, ie, 1 SD of measurement error). Validity of measurements of the rate of change in Mini-Mental State Examination scores improved with longer observation intervals and was reliable for most patients when observations were separated by 3 or more years. Conclusions: Although the Mini-Mental State Examination is a useful screening instrument to assess level of cognitive function, it has limited value in measuring the progression of Alzheimer disease in individual patients for periods less than 3 years because of a large measurement error and substantial variation in change in annual score.

Original languageEnglish
Pages (from-to)857-862
Number of pages6
JournalArchives of neurology
Volume56
Issue number7
DOIs
StatePublished - Jul 1999

Fingerprint

Dive into the research topics of 'Variability in annual mini-mental state examination score in patients with probable Alzheimer disease: A clinical perspective of data from the consortium to establish a registry for Alzheimer's disease'. Together they form a unique fingerprint.

Cite this