Vancomycin trough concentrations in overweight or obese pediatric patients

Daniel E. Heble, Christopher McPherson, Miranda P. Nelson, David A. Hunstad

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


Study Objectives To compare vancomycin trough concentrations in overweight or obese pediatric patients to those with normal body habitus, after initial dosing based on total body weight (TBW). Design Retrospective observational case-control study. Setting Free-standing academic pediatric hospital. Patients Forty-two overweight or obese pediatric patients were matched to 84 children of normal body habitus (NBH). Measurements and Main Results Empiric vancomycin dosing was based on TBW and guided by an age-stratified dosing algorithm previously developed at our center. Initial steady-state vancomycin trough concentrations were retrieved from the electronic medical record. Overweight and obese children had significantly higher initial vancomycin trough concentrations compared with children who had an NBH (median 14.4 μg/ml vs 10.5 μg/ml, p<0.001). Initial vancomycin trough concentrations above 20 μg/ml occurred more often in overweight and obese children (p=0.016). Our dosing algorithm suggested that initial vancomycin trough concentrations below 10 μg/ml occurred significantly more often in children with NBH (p<0.001). Conclusions Overweight and obese pediatric patients may have elevated initial vancomycin trough concentrations when empiric dosing is based on TBW. Special attention to therapeutic drug monitoring is warranted in all children.

Original languageEnglish
Pages (from-to)1273-1277
Number of pages5
Issue number12
StatePublished - Dec 2013


  • obese
  • overweight
  • pediatrics
  • therapeutic drug monitoring
  • vancomycin


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