Valveless pumping behavior of the simulated embryonic heart tube as a function of contractile patterns and myocardial stiffness

Alireza Sharifi, Alex Gendernalik, Deborah Garrity, David Bark

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

During development, the heart begins pumping as a valveless multilayered tube capable of driving blood flow throughout the embryonic vasculature. The mechanical properties and how they interface with pumping function are not well-defined at this stage. Here, we evaluate pumping patterns using a fluid–structure interaction computational model, combined with experimental data and an energetic analysis to investigate myocardial mechanical properties. Through this work, we propose that a myocardium modeled as a Neo-Hookean material with a material constant on the order of 10 kPa is necessary for the heart tube to function with an optimal pressure and cardiac output.

Original languageEnglish
Pages (from-to)2001-2012
Number of pages12
JournalBiomechanics and Modeling in Mechanobiology
Volume20
Issue number5
DOIs
StatePublished - Oct 2021

Keywords

  • Embryonic zebrafish heart
  • Fluid–structure interaction
  • Heart tube
  • Pumping
  • Pumping mechanics
  • Stiffness
  • Valveless pumping at low Reynolds number

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