Value of preoperative esophageal function studies before laparoscopic antireflux surgery

Walter W. Chan, Laura R. Haroian, C. Prakash Gyawali

Research output: Contribution to journalArticlepeer-review

87 Scopus citations


Background The value of esophageal manometry and ambulatory pH monitoring before laparoscopic antireflux surgery (LARS) has been questioned because tailoring the operation to the degree of hypomotility often is not required. This study evaluated a consecutive cohort of patients referred for esophageal function studies in preparation for LARS to determine the rates of findings that would alter surgical decisions. Methods High-resolution manometry (HRM) was performed for each subject using a 21-lumen water-perfused system, and motor function was characterized. Gastroesophageal reflux disease (GERD) was evident from ambulatory pH monitoring if thresholds for acid exposure time and/or positive symptom association probability were passed. Results Of 1,081 subjects (age, 48.4 ± 0.4 years; 56.7% female) undergoing preoperative HRM, 723 (66.9%) also had ambulatory pH testing performed. Lower esophageal sphincter (LES) hypotension (38.9%) and nonspecific spastic disorder (NSSD) of the esophageal body (36.1%) were common. Obstructive LES pathophysiology was noted in 2.5% (achalasia in 1%; incomplete LES relaxation in 1.5%), and significant esophageal body hypomotility in 4.5% (aperistalsis in 3.2%; severe hypomotility in 1.3%) of the subjects. Evidence of GERD was absent in 23.9% of the subjects. Spastic disorders were more frequent in the absence of GERD (43.9% vs. 23.1% with GERD; p<0.0001), whereas hypomotility and normal patterns were more common with GERD. Conclusions Findings considered absolute or relative contraindications for standard 3608 fundoplication are detected in 1 of 14 patients receiving preoperative HRM. Additionally, spastic findings associated with persistent postoperative symptoms are detected at esophageal function testing that could be used in preoperative counseling and candidate selection. Physiologic testing remains important in the preoperative evaluation of patients being considered for LARS.

Original languageEnglish
Pages (from-to)2943-2949
Number of pages7
JournalSurgical endoscopy
Issue number9
StatePublished - Sep 2011


  • Esophageal pH testing
  • Gastroesophageal reflux disease
  • High-resolution esophageal manometry
  • Laparoscopic antireflux surgery


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