Valproic acid enhances the efficacy of radiation therapy by protecting normal hippocampal neurons and sensitizing malignant glioblastoma cells

Keyphrases

• Radiation Therapy 100%
• Hippocampal Neurons 100%
• Glioblastoma Cells 100%
• Valproic Acid 100%
• Acid Treatment 41%
• Tumor Growth 25%
• Cancer Cells 25%
• Neuronal Cells 25%
• Cranial Irradiation 25%
• Dynamic Contrast-enhanced Magnetic Resonance Imaging (DCE-MRI) 16%
• Neurocognitive Deficits 16%
• Mouse Survival 16%
• Glycogen Synthase Kinase 3 (GSK3) 8%
• Hippocampus 8%
• Apoptosis 8%
• Cell Cycle Arrest 8%
• In Cancer 8%
• Cell Culture 8%
• Tumor Model 8%
• Glioma 8%
• Radiotherapy 8%
• Radiation Effects 8%
• Histone Deacetylase 1 (HDAC1) 8%
• Cognitive Deficits 8%
• Cytotoxicity 8%
• Anti-apoptotic Proteins 8%
• Anti-apoptotic Bcl-2 8%
• Heterotopic 8%
• Medulloblastoma 8%
• Radioprotection 8%
• Radiation Damage 8%
• Brain Cancer Cells 8%
• Radiosensitization 8%
• Glioma Tumor 8%
• Subgranular Zone 8%
• Brain Tumor Model 8%
• Orthotopic Glioma 8%
• Brain Neoplasms 8%

Pharmacology, Toxicology and Pharmaceutical Science

• Glioblastoma 100%
• Sodium Valproate 100%
• Tumor Growth 25%
• Malignant Neoplasm 25%
• Tumor Model 16%
• Intracranial Tumor 16%
• Antiapoptotic 8%
• Cell Culture 8%
• Cognitive Defect 8%
• Protein Bcl 2 8%
• Radiosensitizing Agent 8%
• Histone Deacetylase 8%
• Glycogen Synthase Kinase 3 8%
• Brain Cancer 8%
• Radiation-Induced Cytotoxicity 8%
• Medulloblastoma 8%
• Protein Bax 8%

Neuroscience

• Valproic Acid 100%
• Radiation Therapy 100%
• Intracranial Tumor 16%
• Hippocampus 8%
• Cognitive Disorders 8%
• In Vivo 8%
• Magnetic Resonance Imaging 8%
• In Vitro 8%
• Cell Culture 8%
• Cytotoxicity 8%
• Medulloblastoma 8%
• Brain Cancer 8%
• Glycogen Synthase Kinase 3 8%
• Histone Deacetylase 8%
• Protein Bcl 2 8%
• Cell Cycle Arrest 8%
• Cell Cycle Checkpoint 8%
• Radiosensitizer 8%
• Bcl-2-Associated X Protein 8%
• Programmed Cell Death 8%