Valproic acid does not affect markers of human immunodeficiency virus disease progression

Beau M. Ances; Scott Letendre; Maria Buzzell; Jennifer Marquie-Beck; Deborah Lazaretto; Thomas D. Marcotte; Igor Grant; Ronald J. Ellis

doi:10.1080/13550280600981695

Valproic acid does not affect markers of human immunodeficiency virus disease progression

Beau M. Ances, Scott Letendre, Maria Buzzell, Jennifer Marquie-Beck, Deborah Lazaretto, Thomas D. Marcotte, Igor Grant, Ronald J. Ellis

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Valproic acid (VPA) reduces latent human immunodeficiency virus (HIV) reservoirs by activating resting CD4+ cells. This retrospective case-control study (n = 30) examined effects of VPA on markers of HIV progression. VPA was not associated with changes in cerebrospinal fluid viral loads (VL), plasma VL, or neuropsychological performance. VPA patients had a trend towards lower CD4+ cells (P = .08) at follow-up. Concurrent antiretrovirals did not alter these relationships. VPA does not induce viremia or promote disease progression and may be safe for clinical intervention.

Original language	English
Pages (from-to)	403-406
Number of pages	4
Journal	Journal of NeuroVirology
Volume	12
Issue number	5
DOIs	https://doi.org/10.1080/13550280600981695
State	Published - Oct 2006

Keywords

CD4+ cell
HIV
Latent virus
Valproic acid
Viral load

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10.1080/13550280600981695

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title = "Valproic acid does not affect markers of human immunodeficiency virus disease progression",

abstract = "Valproic acid (VPA) reduces latent human immunodeficiency virus (HIV) reservoirs by activating resting CD4+ cells. This retrospective case-control study (n = 30) examined effects of VPA on markers of HIV progression. VPA was not associated with changes in cerebrospinal fluid viral loads (VL), plasma VL, or neuropsychological performance. VPA patients had a trend towards lower CD4+ cells (P = .08) at follow-up. Concurrent antiretrovirals did not alter these relationships. VPA does not induce viremia or promote disease progression and may be safe for clinical intervention.",

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AU - Ances, Beau M.

AU - Letendre, Scott

AU - Buzzell, Maria

AU - Marquie-Beck, Jennifer

AU - Lazaretto, Deborah

AU - Marcotte, Thomas D.

AU - Grant, Igor

AU - Ellis, Ronald J.

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AB - Valproic acid (VPA) reduces latent human immunodeficiency virus (HIV) reservoirs by activating resting CD4+ cells. This retrospective case-control study (n = 30) examined effects of VPA on markers of HIV progression. VPA was not associated with changes in cerebrospinal fluid viral loads (VL), plasma VL, or neuropsychological performance. VPA patients had a trend towards lower CD4+ cells (P = .08) at follow-up. Concurrent antiretrovirals did not alter these relationships. VPA does not induce viremia or promote disease progression and may be safe for clinical intervention.

KW - CD4+ cell

KW - HIV

KW - Latent virus

KW - Valproic acid

KW - Viral load

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Valproic acid does not affect markers of human immunodeficiency virus disease progression

Abstract

Keywords

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