TY - JOUR
T1 - Validity Assessment of an Automated Brain Morphometry Tool for Patients with De Novo Memory Symptoms
AU - Rahmani, F.
AU - Jindal, S.
AU - Raji, C. A.
AU - Wang, Wei
AU - Nazeri, A.
AU - Perez-Carrillo, G. G.
AU - Miller-Thomas, M. M.
AU - Graner, P.
AU - Marechal, B.
AU - Shah, A.
AU - Zimmermann, M.
AU - Chen, C. D.
AU - Keefe, S.
AU - LaMontagne, P.
AU - Benzinger, T. L.S.
N1 - Funding Information:
Data used in this study and the normative data set used by the FS/ILP tool were in-part provided by the OASIS-4 and OASIS-3 cohorts, respectively (https://central.xnat.org/). This database in supported by the following grants: NIH P30AG066444, P50AG00561, P30NS09857781, P01AG026276, P01AG003991, UL1TR000448, R01EB009352 and P30NS098577.
Publisher Copyright:
© 2023 American Society of Neuroradiology. All rights reserved.
PY - 2023/3/1
Y1 - 2023/3/1
N2 - BACKGROUND AND PURPOSE: Automated volumetric analysis of structural MR imaging allows quantitative assessment of brain atrophy in neurodegenerative disorders. We compared the brain segmentation performance of the AI-Rad Companion brain MR imaging software against an in-house FreeSurfer 7.1.1/Individual Longitudinal Participant pipeline. MATERIALS AND METHODS: T1-weighted images of 45 participants with de novo memory symptoms were selected from the OASIS-4 database and analyzed through the AI-Rad Companion brain MR imaging tool and the FreeSurfer 7.1.1/Individual Longitudinal Participant pipeline. Correlation, agreement, and consistency between the 2 tools were compared among the absolute, normalized, and standardized volumes. Final reports generated by each tool were used to compare the rates of detection of abnormality and the compatibility of radiologic impressions made using each tool, compared with the clinical diagnoses. RESULTS: We observed strong correlation, moderate consistency, and poor agreement between absolute volumes of the main cortical lobes and subcortical structures measured by the AI-Rad Companion brain MR imaging tool compared with FreeSurfer. The strength of the correlations increased after normalizing the measurements to the total intracranial volume. Standardized measurements differed significantly between the 2 tools, likely owing to differences in the normative data sets used to calibrate each tool. When considering the FreeSurfer 7.1.1/Individual Longitudinal Participant pipeline as a reference standard, the AI-Rad Companion brain MR imaging tool had a specificity of 90.6%–100% and a sensitivity of 64.3%–100% in detecting volumetric abnormalities. There was no difference between the rate of compatibility of radiologic and clinical impressions when using the 2 tools. CONCLUSIONS: The AI-Rad Companion brain MR imaging tool reliably detects atrophy in cortical and subcortical regions implicated in the differential diagnosis of dementia.
AB - BACKGROUND AND PURPOSE: Automated volumetric analysis of structural MR imaging allows quantitative assessment of brain atrophy in neurodegenerative disorders. We compared the brain segmentation performance of the AI-Rad Companion brain MR imaging software against an in-house FreeSurfer 7.1.1/Individual Longitudinal Participant pipeline. MATERIALS AND METHODS: T1-weighted images of 45 participants with de novo memory symptoms were selected from the OASIS-4 database and analyzed through the AI-Rad Companion brain MR imaging tool and the FreeSurfer 7.1.1/Individual Longitudinal Participant pipeline. Correlation, agreement, and consistency between the 2 tools were compared among the absolute, normalized, and standardized volumes. Final reports generated by each tool were used to compare the rates of detection of abnormality and the compatibility of radiologic impressions made using each tool, compared with the clinical diagnoses. RESULTS: We observed strong correlation, moderate consistency, and poor agreement between absolute volumes of the main cortical lobes and subcortical structures measured by the AI-Rad Companion brain MR imaging tool compared with FreeSurfer. The strength of the correlations increased after normalizing the measurements to the total intracranial volume. Standardized measurements differed significantly between the 2 tools, likely owing to differences in the normative data sets used to calibrate each tool. When considering the FreeSurfer 7.1.1/Individual Longitudinal Participant pipeline as a reference standard, the AI-Rad Companion brain MR imaging tool had a specificity of 90.6%–100% and a sensitivity of 64.3%–100% in detecting volumetric abnormalities. There was no difference between the rate of compatibility of radiologic and clinical impressions when using the 2 tools. CONCLUSIONS: The AI-Rad Companion brain MR imaging tool reliably detects atrophy in cortical and subcortical regions implicated in the differential diagnosis of dementia.
UR - http://www.scopus.com/inward/record.url?scp=85150001329&partnerID=8YFLogxK
U2 - 10.3174/ajnr.A7790
DO - 10.3174/ajnr.A7790
M3 - Article
C2 - 36797031
AN - SCOPUS:85150001329
SN - 0195-6108
VL - 44
SP - 261
EP - 267
JO - American Journal of Neuroradiology
JF - American Journal of Neuroradiology
IS - 3
ER -