TY - JOUR
T1 - Validation of the reference tissue model for estimation of dopaminergic D2-like receptor binding with [18F](N-methyl)benperidol in humans
AU - Antenor-Dorsey, Jo Ann V.
AU - Markham, Joanne
AU - Moerlein, Stephen M.
AU - Videen, Tom O.
AU - Perlmutter, Joel S.
N1 - Funding Information:
Supported by NINDS Grants NS41509, NS50425 and NS31001; Greater St. Louis Chapter of the American Parkinson Disease Association (APDA); APDA Advanced Research Center at Washington University; Barnes Jewish Hospital Foundation (Jack Buck Fund for PD research and Elliot H. Stein Family Fund); and the Murphy Fund and the Kopolow Fund.
PY - 2008/4
Y1 - 2008/4
N2 - Positron emission tomography measurements of dopaminergic D2-like receptors may provide important insights into disorders such as Parkinson's disease, schizophrenia, dystonia and Tourette's syndrome. The positron emission tomography (PET) radioligand [18F](N-methyl)benperidol ([18F]NMB) has high affinity and selectivity for D2-like receptors and is not displaced by endogenous dopamine. The goal of this study is to evaluate the use of a graphical method utilizing a reference tissue region for [18F]-NMB PET analysis by comparisons to an explicit three-compartment tracer kinetic model and graphical method that use arterial blood measurements. We estimated binding potential (BP) in the caudate and putamen using all three methods in 16 humans and found that the three-compartment tracer kinetic method provided the highest BP estimates while the graphical method using a reference region yielded the lowest estimates (P<.0001 by repeated-measures ANOVA). However, the three methods yielded highly correlated BP estimates for the two regions of interest. We conclude that the graphical method using a reference region still provides a useful estimate of BP comparable to methods using arterial blood sampling, especially since the reference region method is less invasive and computationally more straightforward, thereby simplifying these measurements.
AB - Positron emission tomography measurements of dopaminergic D2-like receptors may provide important insights into disorders such as Parkinson's disease, schizophrenia, dystonia and Tourette's syndrome. The positron emission tomography (PET) radioligand [18F](N-methyl)benperidol ([18F]NMB) has high affinity and selectivity for D2-like receptors and is not displaced by endogenous dopamine. The goal of this study is to evaluate the use of a graphical method utilizing a reference tissue region for [18F]-NMB PET analysis by comparisons to an explicit three-compartment tracer kinetic model and graphical method that use arterial blood measurements. We estimated binding potential (BP) in the caudate and putamen using all three methods in 16 humans and found that the three-compartment tracer kinetic method provided the highest BP estimates while the graphical method using a reference region yielded the lowest estimates (P<.0001 by repeated-measures ANOVA). However, the three methods yielded highly correlated BP estimates for the two regions of interest. We conclude that the graphical method using a reference region still provides a useful estimate of BP comparable to methods using arterial blood sampling, especially since the reference region method is less invasive and computationally more straightforward, thereby simplifying these measurements.
KW - Graphical method
KW - [F]NMB
UR - http://www.scopus.com/inward/record.url?scp=40749138662&partnerID=8YFLogxK
U2 - 10.1016/j.nucmedbio.2007.12.004
DO - 10.1016/j.nucmedbio.2007.12.004
M3 - Article
C2 - 18355689
AN - SCOPUS:40749138662
SN - 0969-8051
VL - 35
SP - 335
EP - 341
JO - Nuclear Medicine and Biology
JF - Nuclear Medicine and Biology
IS - 3
ER -