Validation of oxygen extraction fraction measurement by qBOLD technique

Xiang He, Mingming Zhu, Dmitriy A. Yablonskiy

Research output: Contribution to journalArticle

92 Scopus citations

Abstract

Measurement of brain tissue oxygen extraction fraction (OEF) in both baseline and functionally activated states can provide important information on brain functioning in health and disease. The recently proposed quantitative BOLD (qBOLD) technique is MRI-based and provides a regional in vivo OEF measurement (He and Yablonskiy, MRM 2007, 57:115-126). It is based on a previously developed analytical BOLD model and incorporates prior knowledge about the brain tissue composition including the contributions from grey matter, white matter, cerebrospinal fluid, interstitial fluid and intravascular blood. The qBOLD model also allows for the separation of contributions to the BOLD signal from OEF and the deoxyhemoglobin containing blood volume (DBV). The objective of this study is to validate OEF measurements provided by the qBOLD approach. To this end we use a rat model and compare qBOLD OEF measurements against direct measurements of the blood oxygenation level obtained from venous blood drawn directly from the superior sagittal sinus. The cerebral venous oxygenation level of the rat was manipulated by utilizing different anestheisa methods. The study demonstrates a very good agreement between qBOLD approach and direct measurements.

Original languageEnglish
Pages (from-to)882-888
Number of pages7
JournalMagnetic resonance in medicine
Volume60
Issue number4
DOIs
StatePublished - Oct 1 2008

Keywords

  • BOLD
  • Brain hemodynamics
  • Brain metabolism
  • OEF
  • fMRI
  • qBOLD

Fingerprint Dive into the research topics of 'Validation of oxygen extraction fraction measurement by qBOLD technique'. Together they form a unique fingerprint.

  • Cite this