TY - JOUR
T1 - Validation of AD8-Philippines (AD8-P)
T2 - A Brief Informant-Based Questionnaire for Dementia Screening in the Philippines
AU - Dominguez, Jacqueline C.
AU - De Guzman, Ma Fe P.
AU - Joson, Ma Lourdes C.
AU - Fowler, Krizelle
AU - Natividad, Boots P.
AU - Cruz, Precy S.
AU - Jiloca, Jose Leo
AU - MacTal, Primitivo B.
AU - Dominguez, Jayvee Dyne
AU - Domingo, Jeffrey
AU - Dominguez-Awao, Jhozel Kim
AU - Reandelar, MacArio
AU - Javier, Jem R.
AU - Phung, Thien Kieu Thi
AU - Morris, John C.
AU - Galvin, James E.
N1 - Publisher Copyright:
© 2021 Jacqueline C. Dominguez et al.
PY - 2021
Y1 - 2021
N2 - Aim. This study was aimed at validating the Filipino version of AD8 (AD8-P). Methods. Community-dwelling Filipino older persons aged ≥60 years, together with their informants, participated in this study. Psychologists independently interviewed the informants with AD8-P and administered the Filipino-validated Mini-Mental State Examination (MMSE-P) and Montreal Cognitive Assessment (MoCA-P) to the older persons. Neurologists and geriatrician conducted physical and neurological examination and Clinical Dementia Rating™ (CDR™) to determine cognitive diagnosis and were blinded with the results of AD8-P. Dementia was diagnosed based on DSM-IV-TR criteria. AD8-P discriminatory ability to screen for dementia was evaluated according to DSM-IV-TR diagnostic criteria for dementia. Results. A total of 366 community-dwelling Filipino older persons aged ≥60 years, 213 with normal cognition and 153 with dementia, and their informants were included in this study. Majority (90%) were at the mildest stage of dementia. Area under the receiver-operating-characteristic curve (AUROC) for AD8-P was 0.94 (95% CI 0.92 to 0.96), demonstrating excellent overall predictive power to screen for dementia. The optimal AD8-P cut-off score with best balance sensitivity (91.5%) and specificity (77.9%) was ≥3. Conclusion. AD8-P demonstrated good psychometric properties to screen for dementia, even at the earliest stage of cognitive decline.
AB - Aim. This study was aimed at validating the Filipino version of AD8 (AD8-P). Methods. Community-dwelling Filipino older persons aged ≥60 years, together with their informants, participated in this study. Psychologists independently interviewed the informants with AD8-P and administered the Filipino-validated Mini-Mental State Examination (MMSE-P) and Montreal Cognitive Assessment (MoCA-P) to the older persons. Neurologists and geriatrician conducted physical and neurological examination and Clinical Dementia Rating™ (CDR™) to determine cognitive diagnosis and were blinded with the results of AD8-P. Dementia was diagnosed based on DSM-IV-TR criteria. AD8-P discriminatory ability to screen for dementia was evaluated according to DSM-IV-TR diagnostic criteria for dementia. Results. A total of 366 community-dwelling Filipino older persons aged ≥60 years, 213 with normal cognition and 153 with dementia, and their informants were included in this study. Majority (90%) were at the mildest stage of dementia. Area under the receiver-operating-characteristic curve (AUROC) for AD8-P was 0.94 (95% CI 0.92 to 0.96), demonstrating excellent overall predictive power to screen for dementia. The optimal AD8-P cut-off score with best balance sensitivity (91.5%) and specificity (77.9%) was ≥3. Conclusion. AD8-P demonstrated good psychometric properties to screen for dementia, even at the earliest stage of cognitive decline.
UR - http://www.scopus.com/inward/record.url?scp=85118954200&partnerID=8YFLogxK
U2 - 10.1155/2021/7750235
DO - 10.1155/2021/7750235
M3 - Article
C2 - 34754516
AN - SCOPUS:85118954200
SN - 2090-8024
VL - 2021
JO - International Journal of Alzheimer's Disease
JF - International Journal of Alzheimer's Disease
M1 - 7750235
ER -