TY - JOUR
T1 - Vagus Nerve Stimulation for Treatment-Resistant Depression
T2 - Current Status of This Novel Treatment
AU - Conway, Charles R.
AU - Hristidis, Vasilis C.
AU - Gott, Britt M.
AU - Willie, Jon
N1 - Funding Information:
From the Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri (CRC, VCH, BMG); and Neurological Surgery, Washington University School of Medicine, St. Louis, Missouri (JW). Disclosure: Dr. Conway has received research support from NeoSync Inc., Taylor Family Institute for Innovative Psychiatric Research, The American Foundation for Suicide Prevention, Assurex Health Inc., The Brain and Behavior Research Foundation, August Busch IV Foundation, and Barnes-Jewish Hospital Foundation; and received personal fees from and is currently serving as a research consultant to LivaNova PLC. The remaining authors have no relevant financial relationships to disclose. Address correspondence to Charles R. Conway, MD, Department of Psychiatry, Washington University School of Medicine, MSC 8134-17-04, 660 S. Euclid Ave., St. Louis, MO 63110; email: conwaycr@wustl.edu. doi:10.3928/00485713-20220620-01
Publisher Copyright:
© 2022, SLACK Incorporated.
PY - 2022/7
Y1 - 2022/7
N2 - Patients with treatment-resistant or difficult-to-treat major depression (TRD/DTD) have limited proven treatment options. Vagus nerve stimulation (VNS), chronic stimulation of the left cervical vagus nerve using an implant-able pulse generator, has been dem-onstrated in numerous clinical trials to effectively treat TRD/DTD. In this re-view, seminal and ongoing vagus nerve stimulation trials are summarized and compared, and critical clinical findings are discussed.
AB - Patients with treatment-resistant or difficult-to-treat major depression (TRD/DTD) have limited proven treatment options. Vagus nerve stimulation (VNS), chronic stimulation of the left cervical vagus nerve using an implant-able pulse generator, has been dem-onstrated in numerous clinical trials to effectively treat TRD/DTD. In this re-view, seminal and ongoing vagus nerve stimulation trials are summarized and compared, and critical clinical findings are discussed.
UR - http://www.scopus.com/inward/record.url?scp=85136419649&partnerID=8YFLogxK
U2 - 10.3928/00485713-20220620-01
DO - 10.3928/00485713-20220620-01
M3 - Article
AN - SCOPUS:85136419649
SN - 0048-5713
VL - 52
SP - 272
EP - 282
JO - Psychiatric Annals
JF - Psychiatric Annals
IS - 7
ER -