Utility of perfusion PET measures to assess neuronal injury in Alzheimer's disease

Dominantly Inherited Alzheimer Network

doi:10.1016/j.dadm.2018.08.012

Utility of perfusion PET measures to assess neuronal injury in Alzheimer's disease

Dominantly Inherited Alzheimer Network

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Introduction: ¹⁸F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is commonly used to estimate neuronal injury in Alzheimer's disease (AD). Here, we evaluate the utility of dynamic PET measures of perfusion using ¹¹C-Pittsburgh compound B (PiB) to estimate neuronal injury in comparison to FDG PET. Methods: FDG, early frames of PiB images, and relative PiB delivery rate constants (PiB-R1) were obtained from 110 participants from the Dominantly Inherited Alzheimer Network. Voxelwise, regional cross-sectional, and longitudinal analyses were done to evaluate the correlation between images and estimate the relationship of the imaging biomarkers with estimated time to disease progression based on family history. Results: Metabolism and perfusion images were spatially correlated. Regional PiB-R1 values and FDG, but not early frames of PiB images, significantly decreased in the mutation carriers with estimated year to onset and with increasing dementia severity. Discussion: Hypometabolism estimated by PiB-R1 may provide a measure of brain perfusion without increasing radiation exposure.

Original language	English
Pages (from-to)	669-677
Number of pages	9
Journal	Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume	10
DOIs	https://doi.org/10.1016/j.dadm.2018.08.012
State	Published - Jan 1 2018

Keywords

Alzheimer's disease
FDG
Neuronal injury
Perfusion
PiB

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10.1016/j.dadm.2018.08.012

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@article{aab7f7f838ae4219a11a8c591fe88184,

title = "Utility of perfusion PET measures to assess neuronal injury in Alzheimer's disease",

abstract = "Introduction: 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is commonly used to estimate neuronal injury in Alzheimer's disease (AD). Here, we evaluate the utility of dynamic PET measures of perfusion using 11C-Pittsburgh compound B (PiB) to estimate neuronal injury in comparison to FDG PET. Methods: FDG, early frames of PiB images, and relative PiB delivery rate constants (PiB-R1) were obtained from 110 participants from the Dominantly Inherited Alzheimer Network. Voxelwise, regional cross-sectional, and longitudinal analyses were done to evaluate the correlation between images and estimate the relationship of the imaging biomarkers with estimated time to disease progression based on family history. Results: Metabolism and perfusion images were spatially correlated. Regional PiB-R1 values and FDG, but not early frames of PiB images, significantly decreased in the mutation carriers with estimated year to onset and with increasing dementia severity. Discussion: Hypometabolism estimated by PiB-R1 may provide a measure of brain perfusion without increasing radiation exposure.",

keywords = "Alzheimer's disease, FDG, Neuronal injury, Perfusion, PiB",

author = "{Dominantly Inherited Alzheimer Network} and Nelly Joseph-Mathurin and Yi Su and Blazey, {Tyler M.} and Mateusz Jasielec and Andrei Vlassenko and Karl Friedrichsen and Gordon, {Brian A.} and Hornbeck, {Russ C.} and Lisa Cash and Ances, {Beau M.} and Thomas Veale and Cash, {David M.} and Brickman, {Adam M.} and Virginia Buckles and Cairns, {Nigel J.} and Carlos Cruchaga and Alison Goate and Jack, {Clifford R.} and Celeste Karch and William Klunk and Koeppe, {Robert A.} and Marcus, {Daniel S.} and Richard Mayeux and Eric McDade and Noble, {James M.} and John Ringman and Saykin, {Andrew J.} and Thompson, {Paul M.} and Chengjie Xiong and Morris, {John C.} and Bateman, {Randall J.} and Benzinger, {Tammie L.S.}",

note = "Publisher Copyright: {\textcopyright} 2018 The Authors",

year = "2018",

month = jan,

day = "1",

doi = "10.1016/j.dadm.2018.08.012",

language = "English",

volume = "10",

pages = "669--677",

journal = "Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring",

issn = "2352-8729",

}

TY - JOUR

T1 - Utility of perfusion PET measures to assess neuronal injury in Alzheimer's disease

AU - Dominantly Inherited Alzheimer Network

AU - Joseph-Mathurin, Nelly

AU - Su, Yi

AU - Blazey, Tyler M.

AU - Jasielec, Mateusz

AU - Vlassenko, Andrei

AU - Friedrichsen, Karl

AU - Gordon, Brian A.

AU - Hornbeck, Russ C.

AU - Cash, Lisa

AU - Ances, Beau M.

AU - Veale, Thomas

AU - Cash, David M.

AU - Brickman, Adam M.

AU - Buckles, Virginia

AU - Cairns, Nigel J.

AU - Cruchaga, Carlos

AU - Goate, Alison

AU - Jack, Clifford R.

AU - Karch, Celeste

AU - Klunk, William

AU - Koeppe, Robert A.

AU - Marcus, Daniel S.

AU - Mayeux, Richard

AU - McDade, Eric

AU - Noble, James M.

AU - Ringman, John

AU - Saykin, Andrew J.

AU - Thompson, Paul M.

AU - Xiong, Chengjie

AU - Morris, John C.

AU - Bateman, Randall J.

AU - Benzinger, Tammie L.S.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Introduction: 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is commonly used to estimate neuronal injury in Alzheimer's disease (AD). Here, we evaluate the utility of dynamic PET measures of perfusion using 11C-Pittsburgh compound B (PiB) to estimate neuronal injury in comparison to FDG PET. Methods: FDG, early frames of PiB images, and relative PiB delivery rate constants (PiB-R1) were obtained from 110 participants from the Dominantly Inherited Alzheimer Network. Voxelwise, regional cross-sectional, and longitudinal analyses were done to evaluate the correlation between images and estimate the relationship of the imaging biomarkers with estimated time to disease progression based on family history. Results: Metabolism and perfusion images were spatially correlated. Regional PiB-R1 values and FDG, but not early frames of PiB images, significantly decreased in the mutation carriers with estimated year to onset and with increasing dementia severity. Discussion: Hypometabolism estimated by PiB-R1 may provide a measure of brain perfusion without increasing radiation exposure.

AB - Introduction: 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is commonly used to estimate neuronal injury in Alzheimer's disease (AD). Here, we evaluate the utility of dynamic PET measures of perfusion using 11C-Pittsburgh compound B (PiB) to estimate neuronal injury in comparison to FDG PET. Methods: FDG, early frames of PiB images, and relative PiB delivery rate constants (PiB-R1) were obtained from 110 participants from the Dominantly Inherited Alzheimer Network. Voxelwise, regional cross-sectional, and longitudinal analyses were done to evaluate the correlation between images and estimate the relationship of the imaging biomarkers with estimated time to disease progression based on family history. Results: Metabolism and perfusion images were spatially correlated. Regional PiB-R1 values and FDG, but not early frames of PiB images, significantly decreased in the mutation carriers with estimated year to onset and with increasing dementia severity. Discussion: Hypometabolism estimated by PiB-R1 may provide a measure of brain perfusion without increasing radiation exposure.

KW - Alzheimer's disease

KW - FDG

KW - Neuronal injury

KW - Perfusion

KW - PiB

UR - http://www.scopus.com/inward/record.url?scp=85055885481&partnerID=8YFLogxK

U2 - 10.1016/j.dadm.2018.08.012

DO - 10.1016/j.dadm.2018.08.012

M3 - Article

C2 - 30417072

AN - SCOPUS:85055885481

SN - 2352-8729

VL - 10

SP - 669

EP - 677

JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

JF - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

ER -

Utility of perfusion PET measures to assess neuronal injury in Alzheimer's disease

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Keywords

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