Utility of daily image guidance with intensity-modulated radiotherapy for tumors of the base of skull

Allen M. Chen; Suzan Cheng; D. Gregory Farwell; Quang Luu; Paul J. Donald; James Boggan; Stephen Franklin; James A. Purdy

doi:10.1002/hed.21805

Utility of daily image guidance with intensity-modulated radiotherapy for tumors of the base of skull

Allen M. Chen, Suzan Cheng, D. Gregory Farwell, Quang Luu, Paul J. Donald, James Boggan, Stephen Franklin, James A. Purdy

Department of Radiation Oncology

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Background This study was carried out to report our experience using intensity-modulated radiotherapy (IMRT) with daily image-guided radiotherapy (IGRT) for tumors involving the base of skull. Methods In all, 100 patients were prospectively treated with IMRT to a median dose of 64 Gy (range, 45-70 Gy). Daily helical megavoltage computed tomography (MVCT) scans were obtained as part of an IGRT registration protocol for patient alignment. Results The 2-year local-regional control was 91%. A total of 3295 daily MVCT scans were obtained. The mean shift to account for interfraction motion was 1.18 ± 1.75 mm, 1.81 ± 1.34 mm, and 1.33 ± 1.19 mm for the medial-lateral (ML), superior-inferior (SI), and anterior-posterior (AP) directions, respectively. Pretreatment shifts of >3 mm occurred in 10%, 26%, and 18%, in the ML, SI, and AP directions, respectively. Conclusions The feasibility and efficacy of daily IGRT as a complement to IMRT for skull base were demonstrated.

Original language	English
Pages (from-to)	763-770
Number of pages	8
Journal	Head and Neck
Volume	34
Issue number	6
DOIs	https://doi.org/10.1002/hed.21805
State	Published - Jun 2012

Keywords

head and neck cancer
image-guided radiotherapy
intensity-modulated radiotherapy
on-board imaging
skull base

Access to Document

10.1002/hed.21805

Cite this

@article{5cfea913ada549179e767bbf338637b5,

title = "Utility of daily image guidance with intensity-modulated radiotherapy for tumors of the base of skull",

abstract = "Background This study was carried out to report our experience using intensity-modulated radiotherapy (IMRT) with daily image-guided radiotherapy (IGRT) for tumors involving the base of skull. Methods In all, 100 patients were prospectively treated with IMRT to a median dose of 64 Gy (range, 45-70 Gy). Daily helical megavoltage computed tomography (MVCT) scans were obtained as part of an IGRT registration protocol for patient alignment. Results The 2-year local-regional control was 91%. A total of 3295 daily MVCT scans were obtained. The mean shift to account for interfraction motion was 1.18 ± 1.75 mm, 1.81 ± 1.34 mm, and 1.33 ± 1.19 mm for the medial-lateral (ML), superior-inferior (SI), and anterior-posterior (AP) directions, respectively. Pretreatment shifts of >3 mm occurred in 10%, 26%, and 18%, in the ML, SI, and AP directions, respectively. Conclusions The feasibility and efficacy of daily IGRT as a complement to IMRT for skull base were demonstrated.",

keywords = "head and neck cancer, image-guided radiotherapy, intensity-modulated radiotherapy, on-board imaging, skull base",

author = "Chen, {Allen M.} and Suzan Cheng and Farwell, {D. Gregory} and Quang Luu and Donald, {Paul J.} and James Boggan and Stephen Franklin and Purdy, {James A.}",

year = "2012",

month = jun,

doi = "10.1002/hed.21805",

language = "English",

volume = "34",

pages = "763--770",

journal = "Head and Neck",

issn = "1043-3074",

number = "6",

}

TY - JOUR

T1 - Utility of daily image guidance with intensity-modulated radiotherapy for tumors of the base of skull

AU - Chen, Allen M.

AU - Cheng, Suzan

AU - Farwell, D. Gregory

AU - Luu, Quang

AU - Donald, Paul J.

AU - Boggan, James

AU - Franklin, Stephen

AU - Purdy, James A.

PY - 2012/6

Y1 - 2012/6

N2 - Background This study was carried out to report our experience using intensity-modulated radiotherapy (IMRT) with daily image-guided radiotherapy (IGRT) for tumors involving the base of skull. Methods In all, 100 patients were prospectively treated with IMRT to a median dose of 64 Gy (range, 45-70 Gy). Daily helical megavoltage computed tomography (MVCT) scans were obtained as part of an IGRT registration protocol for patient alignment. Results The 2-year local-regional control was 91%. A total of 3295 daily MVCT scans were obtained. The mean shift to account for interfraction motion was 1.18 ± 1.75 mm, 1.81 ± 1.34 mm, and 1.33 ± 1.19 mm for the medial-lateral (ML), superior-inferior (SI), and anterior-posterior (AP) directions, respectively. Pretreatment shifts of >3 mm occurred in 10%, 26%, and 18%, in the ML, SI, and AP directions, respectively. Conclusions The feasibility and efficacy of daily IGRT as a complement to IMRT for skull base were demonstrated.

AB - Background This study was carried out to report our experience using intensity-modulated radiotherapy (IMRT) with daily image-guided radiotherapy (IGRT) for tumors involving the base of skull. Methods In all, 100 patients were prospectively treated with IMRT to a median dose of 64 Gy (range, 45-70 Gy). Daily helical megavoltage computed tomography (MVCT) scans were obtained as part of an IGRT registration protocol for patient alignment. Results The 2-year local-regional control was 91%. A total of 3295 daily MVCT scans were obtained. The mean shift to account for interfraction motion was 1.18 ± 1.75 mm, 1.81 ± 1.34 mm, and 1.33 ± 1.19 mm for the medial-lateral (ML), superior-inferior (SI), and anterior-posterior (AP) directions, respectively. Pretreatment shifts of >3 mm occurred in 10%, 26%, and 18%, in the ML, SI, and AP directions, respectively. Conclusions The feasibility and efficacy of daily IGRT as a complement to IMRT for skull base were demonstrated.

KW - head and neck cancer

KW - image-guided radiotherapy

KW - intensity-modulated radiotherapy

KW - on-board imaging

KW - skull base

UR - http://www.scopus.com/inward/record.url?scp=84861308190&partnerID=8YFLogxK

U2 - 10.1002/hed.21805

DO - 10.1002/hed.21805

M3 - Article

C2 - 21739516

AN - SCOPUS:84861308190

SN - 1043-3074

VL - 34

SP - 763

EP - 770

JO - Head and Neck

JF - Head and Neck

IS - 6

ER -

Utility of daily image guidance with intensity-modulated radiotherapy for tumors of the base of skull

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this