TY - JOUR
T1 - Utility of daily image guidance with intensity-modulated radiotherapy for tumors of the base of skull
AU - Chen, Allen M.
AU - Cheng, Suzan
AU - Farwell, D. Gregory
AU - Luu, Quang
AU - Donald, Paul J.
AU - Boggan, James
AU - Franklin, Stephen
AU - Purdy, James A.
PY - 2012/6/1
Y1 - 2012/6/1
N2 - Background This study was carried out to report our experience using intensity-modulated radiotherapy (IMRT) with daily image-guided radiotherapy (IGRT) for tumors involving the base of skull. Methods In all, 100 patients were prospectively treated with IMRT to a median dose of 64 Gy (range, 45-70 Gy). Daily helical megavoltage computed tomography (MVCT) scans were obtained as part of an IGRT registration protocol for patient alignment. Results The 2-year local-regional control was 91%. A total of 3295 daily MVCT scans were obtained. The mean shift to account for interfraction motion was 1.18 ± 1.75 mm, 1.81 ± 1.34 mm, and 1.33 ± 1.19 mm for the medial-lateral (ML), superior-inferior (SI), and anterior-posterior (AP) directions, respectively. Pretreatment shifts of >3 mm occurred in 10%, 26%, and 18%, in the ML, SI, and AP directions, respectively. Conclusions The feasibility and efficacy of daily IGRT as a complement to IMRT for skull base were demonstrated.
AB - Background This study was carried out to report our experience using intensity-modulated radiotherapy (IMRT) with daily image-guided radiotherapy (IGRT) for tumors involving the base of skull. Methods In all, 100 patients were prospectively treated with IMRT to a median dose of 64 Gy (range, 45-70 Gy). Daily helical megavoltage computed tomography (MVCT) scans were obtained as part of an IGRT registration protocol for patient alignment. Results The 2-year local-regional control was 91%. A total of 3295 daily MVCT scans were obtained. The mean shift to account for interfraction motion was 1.18 ± 1.75 mm, 1.81 ± 1.34 mm, and 1.33 ± 1.19 mm for the medial-lateral (ML), superior-inferior (SI), and anterior-posterior (AP) directions, respectively. Pretreatment shifts of >3 mm occurred in 10%, 26%, and 18%, in the ML, SI, and AP directions, respectively. Conclusions The feasibility and efficacy of daily IGRT as a complement to IMRT for skull base were demonstrated.
KW - head and neck cancer
KW - image-guided radiotherapy
KW - intensity-modulated radiotherapy
KW - on-board imaging
KW - skull base
UR - http://www.scopus.com/inward/record.url?scp=84861308190&partnerID=8YFLogxK
U2 - 10.1002/hed.21805
DO - 10.1002/hed.21805
M3 - Article
C2 - 21739516
AN - SCOPUS:84861308190
VL - 34
SP - 763
EP - 770
JO - Head & Neck
JF - Head & Neck
SN - 1043-3074
IS - 6
ER -